NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
의과대학
의학과
Journal papers
View : 716 Download: 204
Family-based association study of pulmonary function in a population in northeast Asia
Title
Family-based association study of pulmonary function in a population in northeast Asia
Authors
Son
;
H.-Y.
;
Sohn
;
S.-W.
;
Im
;
S.-H.
;
Kim
;
H.-J.
;
Lee
;
M.K.
;
Gombojav
;
B.
;
Kwon
;
H.-S.
;
Park
;
D.S.
;
H.-L.
;
Min
;
K.-U.
;
Sung
;
J.
;
Seo
;
J.-S.
;
J.-I.
Ewha Authors
김형래
SCOPUS Author ID
김형래
Issue Date
2015
Journal Title
PLoS ONE
ISSN
1932-6203
Citation
PLoS ONE vol. 10, no. 10
Publisher
Public Library of Science
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
The spirometric measurement of pulmonary function by measuring the forced expiratory volume in one second (FEV1) is a heritable trait that reflects the physiological condition of the lung and airways. Genome-wide linkage and association studies have identified a number of genes and genetic loci associated with pulmonary function. However, limited numbers of studies have been reported for Asian populations. In this study, we aimed to investigate genetic evidence of pulmonary function in a population in northeast Asia. We conducted a family-based association test with 706 GENDISCAN study participants from 72 Mongolian families to determine candidate genetic determinants of pulmonary function. For the replication, we chose seven candidate single nucleotide polymorphisms (SNPs) from the 5 loci, and tested 1062 SNPs for association with FEV1 from 2,729 subjects of the Korea Healthy Twin study. We identified TMEM132C as a potential candidate gene at 12q24.3, which is a previously reported locus of asthma and spirometric indices. We also found two adjacent candidate genes (UNC93A and TTLL2) in the 6q27 region, which has been previously identified as a pulmonary function locus in the Framingham cohort study. Our findings suggest that novel candidate genes (TMEM132C, UNC93A and TTLL2) in two different regions are associated with pulmonary function in a population in northeast Asia. © 2015 Son et al.
DOI
10.1371/journal.pone.0139716
Appears in Collections:
의과대학
>
의학과
>
Journal papers
Files in This Item:
001.pdf
(795.45 kB)
Download
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject