View : 549 Download: 0
Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production
- Title
- Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production
- Authors
- Choi, Eun Ju; Nam, Sang-Jip; Paul, Lauren; Beatty, Deanna; Kauffman, Christopher A.; Jensen, Paul R.; Fenical, William
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2015
- Journal Title
- CHEMISTRY & BIOLOGY
- ISSN
- 1074-5521
1879-1301
- Citation
- CHEMISTRY & BIOLOGY vol. 22, no. 9, pp. 1270 - 1279
- Publisher
- CELL PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Low-nutrient media and long incubation times facilitated the cultivation of 20 taxonomically diverse Gram-negative marine bacteria within the phyla Bacteroidetes and Proteobacteria. These strains comprise as many as three new families and include members of clades that had only been observed using culture-independent techniques. Chemical studies of the type strains representing two new families within the order Cytophagales led to the isolation of nine new alkaloid secondary metabolites that can be grouped into four distinct structure classes, including azepinones, aziridines, quinolones, and pyrazinones. Several of these compounds possess antibacterial properties and appear, on structural grounds, to be produced by amino acid-based biosynthetic pathways. Our results demonstrate that relatively simple cultivation techniques can lead to the isolation of new bacterial taxa that are capable of the production of alkaloid secondary metabolites with antibacterial activities. These findings support continued investment in cultivation techniques as a method for natural product discovery.
- DOI
- 10.1016/j.chembiol.2015.07.014
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML