Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-29T12:08:09Z | - |
dc.date.available | 2016-08-29T12:08:09Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-15036 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230600 | - |
dc.description.abstract | Abstract A series of novel twenty-eight rigid 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines were synthesized and evaluated for their topoisomerase inhibitory activity as well as their cytotoxicity against several human cancer cell lines. Generally, hydroxylated compounds (16-18, 22-25, and 29-31) containing furyl or thienyl moiety at 4-position of central pyridine exhibited strong topoisomerase I and II inhibitory activity compared to positive control, camptothecin and etoposide, respectively, in low micromolar range. Structure-activity relationship study revealed that indenopyridine compounds with hydroxyl group at 2-phenyl ring in combination with furyl or thienyl moiety at 4-position are important for topoisomerase inhibition. Compounds (22-25) which contain hydroxyl group at meta position of the 2-phenyl ring at 2-position and furanyl or thienyl substitution at 4-position of indenopyridine, showed concrete correlations between topo I and II inhibitory activity, and cytotoxicity against evaluated human cancer cell lines. © 2015 Elsevier Ltd. | * |
dc.language | English | * |
dc.publisher | Elsevier Ltd | * |
dc.subject | Anticancer agents | * |
dc.subject | Cytotoxicity | * |
dc.subject | Hydroxylated 2-phenyl-4-aryl-5Hindeno[1,2-b]pyridines | * |
dc.subject | Topoisomerase I and II inhibitor | * |
dc.title | Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines | * |
dc.type | Article | * |
dc.relation.issue | 13 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3499 | * |
dc.relation.lastpage | 3512 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2015.04.031 | * |
dc.identifier.wosid | WOS:000355848900055 | * |
dc.identifier.scopusid | 2-s2.0-84937409563 | * |
dc.author.google | Kadayat T.M. | * |
dc.author.google | Song C. | * |
dc.author.google | Shin S. | * |
dc.author.google | Magar T.B.T. | * |
dc.author.google | Bist G. | * |
dc.author.google | Shrestha A. | * |
dc.author.google | Thapa P. | * |
dc.author.google | Na Y. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |