- Title
- Uric acid and the kidney
- Authors
- Kang D.-H.
- Ewha Authors
- 강덕희
- SCOPUS Author ID
- 강덕희
- Issue Date
- 2014
- Journal Title
- Core Concepts in Parenchymal Kidney Disease
- Citation
- Core Concepts in Parenchymal Kidney Disease vol. 9781461481669, pp. 375 - 388
- Publisher
- Springer New York
- Indexed
- SCOPUS
- Document Type
- Book Chapter
- Abstract
- Since the primary site of excretion of uric acid is the kidney, plasma concentration of uric acid is mainly determined by renal handling of uric acid. Although hyperuricemia is common in various spectrum of kidney diseases, it historically has been viewed as an issue of limited interest. Recently uric acid has been resurrected as a potential contributory risk factor in the development and progression of renal disease via its direct effect on renal vasculature and tubules as well as indirect effect mediating hypertension and metabolic syndrome. Most studies documented that an elevated serum uric acid level independently predicts the development of chronic kidney disease (CKD), and several interventional studies demonstrated the beneficial effect of lowering plasma uric acid concentrations on preservation of renal function. Uric acid can also induce acute uric acid nephropathy and renal stone via different mechanisms from the progression of renal disease in CKD. In this chapter, the various spectrum of renal disease in hyperuricemic subject will be discussed with a comprehensive review of uric acid-lowering therapy including the use of xanthine oxidase inhibitor and uricosuric agents. © 2014 Springer Science+Business Media New York. All rights are reserved.
- DOI
- 10.1007/978-1-4614-8166-9_26
- ISBN
- 9781461481669
1461481651
9781461481652
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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