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Three-month treatment response and exacerbation in chronic obstructive pulmonary disease
- Title
- Three-month treatment response and exacerbation in chronic obstructive pulmonary disease
- Authors
- Lee J.S.; Rhee C.K.; Yoo K.H.; Lee J.-H.; Yoon .H.I.; Kim T.-H.; Kim W.J.; Lee J.; Lim S.Y.; Park T.S.; Lee S.W.; Lee S.-D.; Oh Y.-M.
- Ewha Authors
- 이진화
- SCOPUS Author ID
- 이진화
- Issue Date
- 2015
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Citation
- Journal of Korean Medical Science vol. 30, no. 1, pp. 54 - 59
- Keywords
- Disease progression; Forced expiratory volume; Pulmonary disease, chronic obstructive
- Publisher
- Korean Academy of Medical Science
- Indexed
- SCI; SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%)were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients. © 2015 The Korean Academy of Medical Sciences.
- DOI
- 10.3346/jkms.2015.30.1.54
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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