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Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

Title
Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea
Authors
Lee S.J.Kim S.W.Kong K.A.Ryu Y.J.Lee J.H.Chang J.H.
Ewha Authors
장중현이진화류연주공경애이석정
SCOPUS Author ID
장중현scopusscopus; 이진화scopusscopus; 류연주scopus; 공경애scopus; 이석정scopusscopus
Issue Date
2015
Journal Title
International Journal of COPD
ISSN
1176-9106JCR Link
Citation
International Journal of COPD vol. 10, pp. 497 - 506
Keywords
Chronic obstructive pulmonary diseaseNever-smokerSocioeconomic status
Publisher
Dove Medical Press Ltd.
Indexed
SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Chronic obstructive pulmonary disease (COPD) patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2), occupational exposure (OR: 2.6; 95% CI: 1.3–5.3), a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7), bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4), male sex (OR: 4.2; 95% CI: 2.6–6.7), advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0), and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4) were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. © 2015 Lee et al.
DOI
10.2147/COPD.S77662
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의과대학 > 의학과 > Journal papers
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