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Suppression of inflammatory cytokine production by ar-turmerone isolated from Curcuma phaeocaulis

Title
Suppression of inflammatory cytokine production by ar-turmerone isolated from Curcuma phaeocaulis
Authors
Oh S.Han A.R.Park H.R.Jang E.J.Kim H.K.Jeong M.G.Song H.Park G.H.Seo E.K.Hwang E.S.
Ewha Authors
서은경황은숙한아름
SCOPUS Author ID
서은경scopus; 황은숙scopus; 한아름scopus
Issue Date
2014
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
Chemistry and Biodiversity vol. 11, no. 7, pp. 1034 - 1041
Keywords
Anti-inflammatory activityar-TurmeroneCurcuma phaeocaulisIFN-γIL-2Rhizomes
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Rhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti-inflammatory properties are a result of cyclooxygenase-2 inhibition; however, its effect on the T-cell function remains to be elucidated. In this study, four known sesquiterpenoids, viz., ar-turmerone (TM), germacrone (GM), (+)-(4S,5S)-germacrone-4,5-epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4+ T-cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4+ T cells, TM suppressed the interferon (IFN)-γ production, without affecting the interleukin (IL)-4 expression. TM also decreased the expression of IL-2 in CD4+ T cells, but did not change their cell-division rates upon stimulation. These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti-inflammatory effects via suppression of the inflammatory cytokines IFN-γ and IL-2. Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.
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DOI
10.1002/cbdv.201300397
Appears in Collections:
약학대학 > 약학과 > Journal papers
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