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dc.contributor.author홍영미-
dc.contributor.author김혜순-
dc.contributor.author손세정-
dc.contributor.author조민선-
dc.contributor.author김관창-
dc.date.accessioned2016-08-28T11:08:06Z-
dc.date.available2016-08-28T11:08:06Z-
dc.date.issued2013-
dc.identifier.issn1783-1061-
dc.identifier.otherOAK-13955-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/229894-
dc.description.abstractPurpose: Tumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model. Methods: Six-week-old male Sprague-Dawley rats were allocated to 3 groups: control (C), single subcutaneous injection of normal saline (0.1 mL/kg); monocrotaline (M), single subcutaneous injection of monocrotaline (60 mg/kg); and monocrotaline + infliximab (M+I), single subcutaneous injection of monocrotaline plus single subcutaneous injection of infliximab (5 mg/kg). The rats were sacrificed after 1, 5, 7, 14, or 28 days. We examined changes in pathology and gene expression levels of TNF-α, endothelin-1 (E T-1), endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS), matrix metalloproteinase (MMP) 2, and tissue inhibitor of matrix metalloproteinase (TIMP). Results: The increase in medial wall thickness of the pulmonary arteriole in the M+I group was significantly lower than that in the M group on day 7 after infliximab treatment (P<0.05). The number of intraacinar muscular arteries in the M+I group was lower than that in the M group on days 14 and 28 (P< 0.05). Expression levels of TNF-α, ET-1, ERA, and MMP2 were significantly lower in the M+I group than in the M group on day 5, whereas eNOS and TIMP expressions were late in the M group (day 28). Conclusion: Infliximab administration induced early changes in pathological findings and expression levels of TNF-α, and MMP2 in a monocrotaline-induced pulmonary hypertension rat model. © 2013 by The Korean Pediatric Society.-
dc.languageEnglish-
dc.titleAn inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotalineinduced pulmonary hypertensive rats model-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume56-
dc.relation.indexSCOPUS-
dc.relation.startpage116-
dc.relation.lastpage124-
dc.relation.journaltitleKorean Journal of Pediatrics-
dc.identifier.doi10.3345/kjp.2013.56.3.116-
dc.identifier.scopusid2-s2.0-84875181979-
dc.author.googleKwon J.H.-
dc.author.googleKim K.C.-
dc.author.googleCho M.-S.-
dc.author.googleKim H.S.-
dc.author.googleSohn S.-
dc.author.googleHong Y.M.-
dc.contributor.scopusid홍영미(35210025100)-
dc.contributor.scopusid김혜순(55663596500)-
dc.contributor.scopusid손세정(56577409300)-
dc.contributor.scopusid조민선(13205279200)-
dc.contributor.scopusid김관창(36652690000)-
dc.date.modifydate20210915163347-
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의과대학 > 의학과 > Journal papers
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