Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.date.accessioned | 2016-08-28T11:08:03Z | - |
dc.date.available | 2016-08-28T11:08:03Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.other | OAK-13285 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229304 | - |
dc.description.abstract | Background and Objectives: Hypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. In particular, matrix metalloproteinase (MMP)-3 is a major enzyme involved in the reconstruction of the arterial intima through activation of other MMPs. We analyzed MMP-3 genotypes in hypertensive and normotensive adolescents and sought to determine if a particular genotype is a predictor of cardiovascular complications. Subjects and Methods: Forty-four hypertensive adolescents and 59 healthy adolescents were included in this study. Serum aldosterone, renin, insulin, angiotensin converting enzyme (ACE), insulin, homocysteine, vitamin B12, folate, MMP-1, MMP-2, MMP-3, MMP-9, tissue inhibitors of matrix metalloproteinases (TIMP)-1, and TIMP-2 were measured. MMP-3 genotypes were analyzed using a polymerase chain reaction (PCR) primer. The carotid intima media thickness (IMT), diameter, and brachial ankle pulse wave velocity (baPWV) were evaluated using ultrasound. Results: In hypertensive adolescents, blood pressure, anthropometric data, carotid IMT, baPWV, serum pro-MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were no different between the 6A/6A group and the 5A/6A group. Serum MMP-9 was higher in the 5A/6A group than in the control group. Aldosterone, insulin, and homocysteine were higher in the 6A/6A group than in the control group, and vitamin B12 and folate were lower in the 6A/6A group than in the control group. Conclusion: In conclusion, serum MMP-3 levels were not significantly different in different MMP-3 genotypes in hypertensive adolescents. However, few patients were included in this study. Further investigation is necessary to clarify the relationship between MMP-3 genotype and cardiovascular risk. Copyright © 2009 The Korean Society of Cardiology. | * |
dc.language | English | * |
dc.title | Metalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adolescents | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 39 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 328 | * |
dc.relation.lastpage | 334 | * |
dc.relation.journaltitle | Korean Circulation Journal | * |
dc.identifier.doi | 10.4070/kcj.2009.39.8.328 | * |
dc.identifier.scopusid | 2-s2.0-70349213345 | * |
dc.author.google | Yun H.L. | * |
dc.author.google | Tae Y.K. | * |
dc.author.google | Young M.H. | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.date.modifydate | 20240415130647 | * |