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dc.contributor.author홍영미-
dc.date.accessioned2016-08-28T11:08:03Z-
dc.date.available2016-08-28T11:08:03Z-
dc.date.issued2009-
dc.identifier.issn1738-5520-
dc.identifier.otherOAK-13285-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/229304-
dc.description.abstractBackground and Objectives: Hypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. In particular, matrix metalloproteinase (MMP)-3 is a major enzyme involved in the reconstruction of the arterial intima through activation of other MMPs. We analyzed MMP-3 genotypes in hypertensive and normotensive adolescents and sought to determine if a particular genotype is a predictor of cardiovascular complications. Subjects and Methods: Forty-four hypertensive adolescents and 59 healthy adolescents were included in this study. Serum aldosterone, renin, insulin, angiotensin converting enzyme (ACE), insulin, homocysteine, vitamin B12, folate, MMP-1, MMP-2, MMP-3, MMP-9, tissue inhibitors of matrix metalloproteinases (TIMP)-1, and TIMP-2 were measured. MMP-3 genotypes were analyzed using a polymerase chain reaction (PCR) primer. The carotid intima media thickness (IMT), diameter, and brachial ankle pulse wave velocity (baPWV) were evaluated using ultrasound. Results: In hypertensive adolescents, blood pressure, anthropometric data, carotid IMT, baPWV, serum pro-MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were no different between the 6A/6A group and the 5A/6A group. Serum MMP-9 was higher in the 5A/6A group than in the control group. Aldosterone, insulin, and homocysteine were higher in the 6A/6A group than in the control group, and vitamin B12 and folate were lower in the 6A/6A group than in the control group. Conclusion: In conclusion, serum MMP-3 levels were not significantly different in different MMP-3 genotypes in hypertensive adolescents. However, few patients were included in this study. Further investigation is necessary to clarify the relationship between MMP-3 genotype and cardiovascular risk. Copyright © 2009 The Korean Society of Cardiology.-
dc.languageEnglish-
dc.titleMetalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adolescents-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume39-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage328-
dc.relation.lastpage334-
dc.relation.journaltitleKorean Circulation Journal-
dc.identifier.doi10.4070/kcj.2009.39.8.328-
dc.identifier.scopusid2-s2.0-70349213345-
dc.author.googleYun H.L.-
dc.author.googleTae Y.K.-
dc.author.googleYoung M.H.-
dc.contributor.scopusid홍영미(35210025100)-
dc.date.modifydate20200901081003-
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의과대학 > 의학과 > Journal papers
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