View : 234 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author유권-
dc.contributor.author정성애-
dc.contributor.author이주호-
dc.contributor.author심기남-
dc.contributor.author김성은-
dc.date.accessioned2016-08-28T11:08:59Z-
dc.date.available2016-08-28T11:08:59Z-
dc.date.issued2009-
dc.identifier.issn1976-2283-
dc.identifier.otherOAK-13236-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/229259-
dc.description.abstractBackground/Aims: Hypoxia-inducible factor-1α (HIF-1α) is a mediator of tumor progression. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor known to be induced by HIF-1α. We investigated the clinicopathological significance of HIF-1α and VEGF levels in biopsied gastric cancer tissue. Methods: Endoscopic biopsy specimens from 67 patients with gastric carcinoma who underwent surgery were available for this study. Semiquantitative RT-PCR was applied to biopsied tumors and normal tissues to determine the expressions of HIF-1α and VEGF. The expression levels of HIF-1α and VEGF were evaluated using the tumor:normal (T/N) ratios of HIF-1α and VEGF mRNA. The clinicopathological variables were reviewed retrospectively. Results: The T/N ratios of HIF-1α mRNA showed significant correlation with lymph-node metastases, distant metastases, stage, and recurrence within 3 years (p<0.05). The T/N ratios of VEGF mRNA showed significant correlation with lymph-node metastases and distant metastases (p<0.05). There was a significant correlation between the T/N ratios of HIF-1α and VEGF mRNA (r=0.72, p<0.01). Conclusions: The increased expression of HIF-1α and VEGF mRNA could reflect aggressive tumor behavior, including the recurrence of gastric cancer. Examination of HIF-1α mRNA in biopsy specimens by RT-PCR assay might provide useful preoperative information on tumor aggressiveness.-
dc.languageEnglish-
dc.titleThe clinicopathological significance of tissue levels of hypoxia-inducible factor-1α and vascular endothelial growth factor in gastric cancer-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume3-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage88-
dc.relation.lastpage94-
dc.relation.journaltitleGut and Liver-
dc.identifier.doi10.5009/gnl.2009.3.2.88-
dc.identifier.wosidWOS:000266715700003-
dc.identifier.scopusid2-s2.0-67649300463-
dc.author.googleKim S.-E.-
dc.author.googleShim K.-N.-
dc.author.googleJung S.-A.-
dc.author.googleYoo K.-
dc.author.googleJoo H.L.-
dc.contributor.scopusid유권(7202592827)-
dc.contributor.scopusid정성애(7403676915)-
dc.contributor.scopusid이주호(55689891300)-
dc.contributor.scopusid심기남(13604838300)-
dc.contributor.scopusid김성은(35210756100)-
dc.date.modifydate20190113081002-
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE