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Two new stereoisomers of neolignan and lignan from the flower buds of magnolia fargesii
- Title
- Two new stereoisomers of neolignan and lignan from the flower buds of magnolia fargesii
- Authors
- Lee J.; Seo E.-K.; Jang D.S.; Ha T.J.; Jong-Pyung K.I.M.; Nam J.-W.; Bae G.; Lee Y.M.; Yang M.S.; Kim J.S.
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2009
- Journal Title
- Chemical and Pharmaceutical Bulletin
- ISSN
- 0009-2363
- Citation
- Chemical and Pharmaceutical Bulletin vol. 57, no. 3, pp. 298 - 301
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new stereoisomer of 8-O-4′ system neolignan, (7R,8S)-1-(3,4- dimethoxyphenyl)-2-[4-(3-hydroxy-1-propenyl)-2-methoxyphenoxy]-propane-1,3-diol (1) and a new stereoisomer of tetrahydrofuranoid lignan, (7R,8S,7'S,8'R)-(3,4,5, 3′,4′)-pentamethoxy-9,7′-dihydroxy-8.8′,7.0. 9′-lignan (2) along with seven known lignans and neolignans (3-9) were isolated from the methanol extracts of the flower buds of Magnolia fargesii. The structures of these compounds (1-9) were elucidated by spectroscopic methods including 1D- and 2D-NMR as well as by comparison with reported values. Absolute configurations of new stereoisomers 1 and 2 were determined by circular dichroism (CD) spectra. The absolute configuration of (S,8S,10S)-[tetrahydro-4- hydroxy-2-(3,4,5-tri-methoxyphenyl)furan-3-yl]methyl 3,4-dimethoxy benzoate (3) was determined by Mosher's esterification method for the first time in this study. Three lignans, tanegool (4), (+)-dehydrodiconiferyl alcohol (5), and epieudes-min (6), were isolated from this plant for the first time. Superoxide radical scavenging activities of the isolates (1-9) were measured by irradiated riboflavin/ethylenediaminetetraacetic acid (EDTA)/Nitroblue tetrazolium (NBT) system, and their in vitro rat lens aldose reductase (RLAR) inhibitory activities were also evaluated. © 2009 Pharmaceutical Society of Japan.
- DOI
- 10.1248/cpb.57.298
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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