Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T11:08:23Z | - |
dc.date.available | 2016-08-28T11:08:23Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-12778 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228852 | - |
dc.description.abstract | We recently reported that the ginseng saponin metabolite, compound K (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits the growth of U937 cells through caspase-dependent apoptosis pathway. In this study, we further characterized the effects of compound K on U937 cells and found that, in addition to apoptosis, compound K induced the arrest of the G1 phase. The compound K treated U937 cells showed increased p21 expression; an inhibitory protein of cyclin-cdk complex. The up-regulation of p21 was followed by the inactivation of cyclin D and the cdk4 protein, which act at the early G1 phase, and cyclin E, which acts at the late G1 phase. Furthermore, compound K induced the activation of JNK and the transcription factor AP-1, which is a downstream target of JNK. These findings suggest that the up-regulation of p21 and activation of JNK in the compound K treated cells contribute to the arrest of the G1 phase. | * |
dc.language | English | * |
dc.title | G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 28 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 685 | * |
dc.relation.lastpage | 690 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/BF02969359 | * |
dc.identifier.wosid | WOS:000230180000009 | * |
dc.identifier.scopusid | 2-s2.0-24944471446 | * |
dc.author.google | Kyoung A.K. | * |
dc.author.google | Yeong W.K. | * |
dc.author.google | Seung U.K. | * |
dc.author.google | Chae S. | * |
dc.author.google | Young S.K. | * |
dc.author.google | Hee S.K. | * |
dc.author.google | Min K.C. | * |
dc.author.google | Dong H.K. | * |
dc.author.google | Jin W.H. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |