Solvent effect on rate for anionic nucleophilic substitution reaction of 4-nitrophenyl acetate in aqueous acetonitrile

Abstract

Second order rate constants have been measured for anionic nucleophilic substitution reactions of 4-nitrophenyl acetate in MeCN-H2O mixtures. The results show rate minima near 30-40 mole % MeCN, which are attributed to changes in solvent structure.