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Combined effects of hepatocyte nuclear factor 4 alpha and constitutive androstane receptor on stable warfarin doses

Title
Combined effects of hepatocyte nuclear factor 4 alpha and constitutive androstane receptor on stable warfarin doses
Authors
Moon, Jung YeonLee, Kyung EunChang, Byung ChulJeong, EurimJeong, HotcherlGwak, Hye Sun
Ewha Authors
곽혜선정호철
SCOPUS Author ID
정호철scopus
Issue Date
2015
Journal Title
PHARMACOGENETICS AND GENOMICS
ISSN
1744-6872JCR Link

1744-6880JCR Link
Citation
PHARMACOGENETICS AND GENOMICS vol. 25, no. 1, pp. 38 - 40
Keywords
constitutive androstane receptorCYP2C9hepatocyte nuclear factor 4transcription factorwarfarin
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A possible association between the combination of genetic variations in hepatocyte nuclear factor 4 (HNF4) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4 (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4 genotypes could be determinants of stable warfarin doses. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
DOI
10.1097/FPC.0000000000000103
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약학대학 > 약학과 > Journal papers
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