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Combined effects of hepatocyte nuclear factor 4 alpha and constitutive androstane receptor on stable warfarin doses

Title
Combined effects of hepatocyte nuclear factor 4 alpha and constitutive androstane receptor on stable warfarin doses
Authors
Moon, Jung YeonLee, Kyung EunChang, Byung ChulJeong, EurimJeong, HotcherlGwak, Hye Sun
Ewha Authors
곽혜선정호철
SCOPUS Author ID
곽혜선scopus; 정호철scopus
Issue Date
2015
Journal Title
PHARMACOGENETICS AND GENOMICS
ISSN
1744-6872JCR Link

1744-6880JCR Link
Citation
PHARMACOGENETICS AND GENOMICS vol. 25, no. 1, pp. 38 - 40
Keywords
constitutive androstane receptorCYP2C9hepatocyte nuclear factor 4transcription factorwarfarin
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A possible association between the combination of genetic variations in hepatocyte nuclear factor 4 (HNF4) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4 (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4 genotypes could be determinants of stable warfarin doses. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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DOI
10.1097/FPC.0000000000000103
Appears in Collections:
약학대학 > 약학과 > Journal papers
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