Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배윤수 | * |
dc.contributor.author | 이수영 | * |
dc.contributor.author | 김재상 | * |
dc.date.accessioned | 2016-08-28T11:08:53Z | - |
dc.date.available | 2016-08-28T11:08:53Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.other | OAK-11920 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228225 | - |
dc.description.abstract | 2-(Trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient megakaryopoiesis. Here, we show that (R)-TEMOSPho blocks osteoclast maturation from pro-genitor cells of hematopoietic origin, as well as blocking the resorptive function of mature osteoclasts. The inhibitory effect of (R)-TEMOSPho on osteoclasts was due to a disruption of the actin cytoskeleton, resulting from impaired downstream signaling of c-Fms, a receptor for macro-phage-colony stimulating factor linked to c-Cbl, phosphoinositol-3-kinase (PI3K), Vav3, and Rac1. In addition, (R)-TEMOSPho blocked inflammation-induced bone destruction by reducing the numbers of osteoclasts produced in mice. Thus, (R)-TEMOSPho may represent a promising new class of antiresorptive drugs for the treatment of bone loss associated with increased osteoclast maturation and activity. © The Korean Society for Molecular and Cellular Biology. All rights reserved. | * |
dc.language | English | * |
dc.publisher | Korean Society for Molecular and Cellular Biology | * |
dc.subject | (R)-TEMOSPho | * |
dc.subject | Antiresorptive drugs | * |
dc.subject | Bone destruction | * |
dc.subject | Osteoclast | * |
dc.subject | Osteoclast maturation | * |
dc.title | 2-(trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate suppresses osteoclast maturation and bone resorption by targeting macrophage-colony stimulating factor signaling | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 628 | * |
dc.relation.lastpage | 635 | * |
dc.relation.journaltitle | Molecules and Cells | * |
dc.identifier.doi | 10.14348/molcells.2014.0190 | * |
dc.identifier.wosid | WOS:000342561500009 | * |
dc.identifier.scopusid | 2-s2.0-84950159270 | * |
dc.author.google | Park S.J. | * |
dc.author.google | Park D.R. | * |
dc.author.google | Bhattarai D. | * |
dc.author.google | Lee K. | * |
dc.author.google | Kim J. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.date.modifydate | 20240415133331 | * |