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Anti-adipogenic activity of the naturally occurring phenanthroindolizidine alkaloid antofine via direct suppression of PPARγ expression

Title
Anti-adipogenic activity of the naturally occurring phenanthroindolizidine alkaloid antofine via direct suppression of PPARγ expression
Authors
Jang E.J.Kim H.K.Jeong H.Lee Y.S.Jeong M.G.Bae S.J.Kim S.Lee S.K.Hwang E.S.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2014
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
Chemistry and Biodiversity vol. 11, no. 6, pp. 962 - 969
Keywords
Adipocyte differentiationAlkaloidsAnit-adipogenic activityAntofinePhenanthroindolizidine alkaloidsPPARγ
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Antofine (ANTF) is a phenanthroindolizidine alkaloid isolated from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae), which is used as an herbal remedy for pain and inflammation. ANTF also possesses antiviral and antitumorigenic activities. In this study, we investigated the role of ANTF in adipogenesis. Chronic ABTF administration suppressed adipocyte differentiation and marker expression in a dose-dependent manner. Furthermore, acute administration of ANTF at early stages of differentiation process inhibited lipid droplet formation and adipogenic gene expression. ANTF Treatment decreased expression of PPARγ protein, a master transcription factor in the regulation of adipocyte differentiation, leading to a suppression of aP2 promoter activity. These results suggest that ANTF exerts potent anti-adipogenic effects via direct suppression of PPARγ protein expression, with consequent downregulation of adipogenic gene expression. Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.
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DOI
10.1002/cbdv.201300365
Appears in Collections:
약학대학 > 약학과 > Journal papers
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