Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박은미 | * |
dc.contributor.author | 최지하 | * |
dc.date.accessioned | 2016-08-28T11:08:14Z | - |
dc.date.available | 2016-08-28T11:08:14Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1744-6872 | * |
dc.identifier.other | OAK-10758 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/227281 | - |
dc.description.abstract | Objective Human multidrug and toxin extrusion member 2 (MATE2-K, SLC47A2) plays an important role in the renal elimination of various clinical drugs including the antidiabetic drug metformin. The goal of this study was to characterize genetic variants of MATE2-K and determine their association with the pharmacokinetics of metformin. Methods We screened DNA samples from 48 healthy Koreans for variants in the promoter and coding regions ofMATE2-K and examined the function of common haplotypes in the promoter region using in-vitro luciferase assays. Then, the metformin pharmacokinetic study was carried out to determine the association between MATE2-K promoter haplotypes and metformin pharmacokinetics. Results Nine variants in the promoter region of MATE2-K and one nonsynonymous variant, p.G211V, were identified. The MATE2-K promoter haplotype 1 containing a known functional polymorphism, g.-130G< A and haplotype 2 containing two polymorphisms, g.-609G<A and g.-396G< A showed a significant increase in reporter activity. Among the 45 individuals who participated in the metformin pharmacokinetic study, 12 healthy Koreans who were homozygous for haplotype 1 or 2 showed a significant increase in renal clearance [539±76 (reference group) vs. 633±102 (variant group) ml/min; P= 0.006] and secretion clearance [439±81 (reference group) vs. 531±102 (variant group) ml/min; P = 0.007] of metformin compared with that shown by the reference group. Conclusion Our study suggests that common promoter haplotypes of MATE2-K are associated with the pharmacokinetics of metformin. © Lippincott Williams & Wilkins. | * |
dc.language | English | * |
dc.title | Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 365 | * |
dc.relation.lastpage | 373 | * |
dc.relation.journaltitle | Pharmacogenetics and Genomics | * |
dc.identifier.doi | 10.1097/FPC.0b013e3283622037 | * |
dc.identifier.wosid | WOS:000327694900005 | * |
dc.identifier.scopusid | 2-s2.0-84879128112 | * |
dc.author.google | Chung J.Y. | * |
dc.author.google | Cho S.K. | * |
dc.author.google | Kim T.H. | * |
dc.author.google | Kim K.H. | * |
dc.author.google | Jang G.H. | * |
dc.author.google | Kim C.O. | * |
dc.author.google | Park E.M. | * |
dc.author.google | Cho J.Y. | * |
dc.author.google | Jang I.J. | * |
dc.author.google | Choi J.H. | * |
dc.contributor.scopusid | 박은미(35933416400) | * |
dc.contributor.scopusid | 최지하(35080057300) | * |
dc.date.modifydate | 20240123095000 | * |