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dc.contributor.author박혜영-
dc.date.accessioned2016-08-28T10:08:25Z-
dc.date.available2016-08-28T10:08:25Z-
dc.date.issued2013-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-10396-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223988-
dc.description.abstractThe exclusive distribution of 5-HT6 receptor in the brain regions and high affinity for antipsychotic and antidepressant drugs makes 5-HT6 receptor a promising target in treatment of CNS diseases. Based on a pharmacophore model reported in the literature, we designed and synthesized a novel series of 5-HT6 receptor ligands having indole as a central aromatic core and 1-amino-4-methyl piperazine as positive ionizable group. Out of 32 compounds we have successfully identified 10 new compounds as 5-HT6 receptor antagonists. The structure-activity relationship (SAR) studies have been carried out by mapping the compounds with the 3D QSAR model. © 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleDesign and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group-
dc.typeArticle-
dc.relation.issue17-
dc.relation.volume21-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage5573-
dc.relation.lastpage5582-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2013.05.051-
dc.identifier.wosidWOS:000323294600075-
dc.identifier.scopusid2-s2.0-84881376737-
dc.author.googleHayat F.-
dc.author.googleCho S.-
dc.author.googleRhim H.-
dc.author.googleIndu Viswanath A.N.-
dc.author.googlePae A.N.-
dc.author.googleLee J.Y.-
dc.author.googleChoo D.J.-
dc.author.googleChoo H.-Y.P.-
dc.contributor.scopusid박혜영(34972649500)-
dc.date.modifydate20190301081000-
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약학대학 > 약학과 > Journal papers
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