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Thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, suppresses angiogenesis by regulating PI3K/AKT/mTOR and ERK signaling in endothelial cells

Title
Thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, suppresses angiogenesis by regulating PI3K/AKT/mTOR and ERK signaling in endothelial cells
Authors
Kim G.D.Oh J.Jeong L.S.Lee S.K.
Ewha Authors
정낙신
SCOPUS Author ID
정낙신scopus
Issue Date
2013
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
Biochemical and Biophysical Research Communications vol. 437, no. 1, pp. 79 - 86
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Although A3AR agonists exhibit a variety of biological activities including anticancer effects, their possible anti-angiogenic effects have not yet been investigated. In the present study, we assayed the anti-angiogenic activity of thio-Cl-IB-MECA, a novel A3AR agonist, in cultured HUVECs and mES/EB-derived endothelial cells. Thio-Cl-IB-MECA inhibited migration and tube formation by endothelial cells and dramatically decreased ex vivo microvessel sprouting in cultured mouse aortic rings. The anti-angiogenic activity of thio-Cl-IB-MECA was associated with suppression of the expression of the endothelial biomarker PECAM via regulation of PI3K/AKT/mTOR and ERK signaling in mES/EB-derived endothelial cells. © 2013 Elsevier Inc.
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DOI
10.1016/j.bbrc.2013.06.040
Appears in Collections:
약학대학 > 약학과 > Journal papers
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