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dc.contributor.author윤여준-
dc.date.accessioned2016-08-28T10:08:18Z-
dc.date.available2016-08-28T10:08:18Z-
dc.date.issued2013-
dc.identifier.issn2161-5063-
dc.identifier.otherOAK-10314-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223917-
dc.description.abstractThe polyketide synthase (PKS) biosynthetic code has recently expanded to include a newly recognized group of extender unit substrates derived from α,β-unsaturated acyl-CoA molecules that deliver diverse side chain chemistry to polyketide backbones. Herein we report the identification of a three-gene operon responsible for the biosynthesis of the PKS building block isobutyrylmalonyl-CoA associated with the macrolide ansalactam A from the marine bacterium Streptomyces sp. CNH189. Using a synthetic biology approach, we engineered the production of unnatural 36-methyl-FK506 in Streptomyces sp. KCTC 11604BP by incorporating the branched extender unit into FK506 biosynthesis in place of its natural C-21 allyl side chain, which has been shown to be critical for FK506's potent immunosuppressant and neurite outgrowth activities. © 2012 American Chemical Society.-
dc.languageEnglish-
dc.titleDesigned biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume2-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage379-
dc.relation.lastpage383-
dc.relation.journaltitleACS Synthetic Biology-
dc.identifier.doi10.1021/sb3001062-
dc.identifier.wosidWOS:000322210200004-
dc.identifier.scopusid2-s2.0-84880530282-
dc.author.googleLechner A.-
dc.author.googleWilson M.C.-
dc.author.googleBan Y.H.-
dc.author.googleHwang J.-Y.-
dc.author.googleYoon Y.J.-
dc.author.googleMoore B.S.-
dc.contributor.scopusid윤여준(7402126465)-
dc.date.modifydate20210708161345-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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