Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성연아 | * |
dc.contributor.author | 오지영 | * |
dc.contributor.author | 이혜진 | * |
dc.date.accessioned | 2016-08-28T10:08:14Z | - |
dc.date.available | 2016-08-28T10:08:14Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1226-3303 | * |
dc.identifier.other | OAK-10275 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223882 | - |
dc.description.abstract | Background/Aims: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNF-α, adiponectin, and IGFBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. Methods: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI ≥ 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Anthropometric measurements were performed, and serum levels of TNF-α, adiponectin, and IGFBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. Results: Serum levels of TNF-α and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p < 0.05). TNF-α, adiponectin, and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adiponectin levels and MCR (p < 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p < 0.05) in women with PCOS. Conclusions: IGFBP-3 and TNF-α levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS. © 2013 The Korean Association of Internal Medicine. | * |
dc.language | English | * |
dc.title | Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 28 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 456 | * |
dc.relation.lastpage | 463 | * |
dc.relation.journaltitle | Korean Journal of Internal Medicine | * |
dc.identifier.doi | 10.3904/kjim.2013.28.4.456 | * |
dc.identifier.wosid | WOS:000321538500010 | * |
dc.identifier.scopusid | 2-s2.0-84880443499 | * |
dc.author.google | Lee H. | * |
dc.author.google | Oh J.-Y. | * |
dc.author.google | Sung Y.-A. | * |
dc.contributor.scopusid | 성연아(18435369300) | * |
dc.contributor.scopusid | 오지영(7402155254) | * |
dc.contributor.scopusid | 이혜진(56192810300) | * |
dc.date.modifydate | 20240123102249 | * |