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dc.contributor.author성연아-
dc.contributor.author오지영-
dc.contributor.author이혜진-
dc.date.accessioned2016-08-28T10:08:14Z-
dc.date.available2016-08-28T10:08:14Z-
dc.date.issued2013-
dc.identifier.issn1226-3303-
dc.identifier.otherOAK-10275-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223882-
dc.description.abstractBackground/Aims: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNF-α, adiponectin, and IGFBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. Methods: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI ≥ 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Anthropometric measurements were performed, and serum levels of TNF-α, adiponectin, and IGFBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. Results: Serum levels of TNF-α and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p < 0.05). TNF-α, adiponectin, and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adiponectin levels and MCR (p < 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p < 0.05) in women with PCOS. Conclusions: IGFBP-3 and TNF-α levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS. © 2013 The Korean Association of Internal Medicine.-
dc.languageEnglish-
dc.titleAdipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume28-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage456-
dc.relation.lastpage463-
dc.relation.journaltitleKorean Journal of Internal Medicine-
dc.identifier.doi10.3904/kjim.2013.28.4.456-
dc.identifier.wosidWOS:000321538500010-
dc.identifier.scopusid2-s2.0-84880443499-
dc.author.googleLee H.-
dc.author.googleOh J.-Y.-
dc.author.googleSung Y.-A.-
dc.contributor.scopusid성연아(18435369300)-
dc.contributor.scopusid오지영(7402155254)-
dc.contributor.scopusid이혜진(56192810300)-
dc.date.modifydate20220317130948-
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의과대학 > 의학과 > Journal papers
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