View : 233 Download: 0
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in drosophila
- Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in drosophila
- Lee K.-A.; Kim S.-H.; Kim E.-K.; Ha E.-M.; You H.; Kim B.; Kim M.-J.; Kwon Y.; Ryu J.-H.; Lee W.-J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Cell vol. 153, no. 4, pp. 797 - 811
- SCIE; SCOPUS
- Document Type
Show the fulltext
- All metazoan guts are subjected to immunologically unique conditions in which an efficient antimicrobial system operates to eliminate pathogens while tolerating symbiotic commensal microbiota. However, the molecular mechanisms controlling this process are only partially understood. Here, we show that bacterial-derived uracil acts as a ligand for dual oxidase (DUOX)-dependent reactive oxygen species generation in Drosophila gut and that the uracil production in bacteria causes inflammation in the gut. The acute and controlled uracil-induced immune response is required for efficient elimination of bacteria, intestinal cell repair, and host survival during infection of nonresident species. Among resident gut microbiota, uracil production is absent in symbionts, allowing harmonious colonization without DUOX activation, whereas uracil release from opportunistic pathobionts provokes chronic inflammation. These results reveal that bacteria with distinct abilities to activate uracil-induced gut inflammation, in terms of intensity and duration, act as critical factors that determine homeostasis or pathogenesis in gut-microbe interactions. © 2013 Elsevier Inc.
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.