Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이희승 | * |
dc.date.accessioned | 2016-08-28T10:08:51Z | - |
dc.date.available | 2016-08-28T10:08:51Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.other | OAK-10015 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223662 | - |
dc.description.abstract | Purpose: Nociceptin/orphanin FQ (N/OFQ) as an endogeneous hexadecapeptide is known to exert antinociceptive effects spinally. The aims of this study were to demonstrate the antinociceptive effects of i.t. N/OFQ and to investigate the possible interaction between N/OFQ and endogenous opioid systems using selective opioid receptor antagonists in rat formalin tests. Materials and Methods: I.t. N/ OFQ was injected in different doses (1-10 nmol) via a lumbar catheter prior to a 50 μL injection of 5% formalin into the right hindpaw of rats. Flinching responses were measured from 0-10 min (phase I, an initial acute state) and 11-60 min (phase II, a prolonged tonic state). To observe which opioid receptors are involved in the anti-nociceptive effect of i.t. N/OFQ in the rat-formalin tests, naltrindole (5-20 nmol), β-funaltrexamine (1-10 nmol), and norbinaltorphimine (10 nmol), selective δ-, μ- and κ-opioid receptor antagonists, respectively, were administered intra-thecally 5 min after i.t. N/OFQ. Results: I.t. N/OFQ attenuated the formalin-induced flinching responses in a dose-dependent manner in both phases I and II. I.t. administration of naltrindole and β-funaltrexamine dose-dependently reversed the N/OFQ-induced attenuation of flinching responses in both phases; however, norbinaltorphimine did not. Conclusion: I.t. N/OFQ exerted an antinociceptive effect in both phases of the rat-formalin test through the nociceptin opioid peptide receptor. In addition, the results suggested that δ- and μ-opioid receptors, but not κ-opioid receptors, are involved in the antinociceptive effects of N/OFQ in the spinal cord of rats. © Yonsei University College of Medicine 2013. | * |
dc.language | English | * |
dc.title | Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 54 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 763 | * |
dc.relation.lastpage | 771 | * |
dc.relation.journaltitle | Yonsei Medical Journal | * |
dc.identifier.doi | 10.3349/ymj.2013.54.3.763 | * |
dc.identifier.wosid | WOS:000317942600033 | * |
dc.identifier.scopusid | 2-s2.0-84875876642 | * |
dc.author.google | Lee H. | * |
dc.contributor.scopusid | 이희승(57216677572) | * |
dc.date.modifydate | 20240419142459 | * |