Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이화정 | * |
dc.contributor.author | 윤여준 | * |
dc.contributor.author | 최진호 | * |
dc.contributor.author | 박제원 | * |
dc.date.accessioned | 2016-08-28T10:08:49Z | - |
dc.date.available | 2016-08-28T10:08:49Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0947-6539 | * |
dc.identifier.other | OAK-9983 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223636 | - |
dc.description.abstract | Poor aqueous solubility and the unpleasant taste of aripiprazole (APZ) have been recurring problems, owing to its low bioavailability and low patient tolerance, respectively. Herein, we prepared a nanohybrid system that was based on a bentonite clay material, montmorillonite (MMT), which could both mask the taste and enhance the solubility of APZ (i.e., APZ-MMT). To further improve the efficacy of this taste masking and drug solubility, APZ-MMT was also coated with a cationic polymer, polyvinylacetal diethylamino acetate (AEA). In vitro dissolution tests at neutral pH showed that the amount of drug that was released from the AEA-coated APZ-MMT was greatly suppressed (<1 %) for the first 3 min, thus suggesting that AEA-coated APZ-MMT has strong potential for the taste masking of APZ. Notably, in simulated gastric juice at pH 1.2, the total percentage of APZ that was released within the first 2 h increased up to 95 % for AEA-coated APZ-MMT. Furthermore, this in vitro release profile was also similar to that of Abilify®, a commercially available medication. In vivo experiments by using Sprague-Dawley rats were also performed to compare the pharmacokinetics of AEA-coated APZ-MMT and Abilify®. AEA-coated APZ-MMT exhibited about 20 % higher systemic exposure of APZ and its metabolite, dehydro-APZ, compared with Abilify®. Therefore, a new MMT-based nanovehicle, which is coated with a cationic polymer, can act as a promising delivery system for both taste masking and for enhancing the bioavailability of APZ. Please release me: From an in vitro release study, the drug-release fraction for the AEA-coated aripiprazole-montmorillonite (APZ-MMT) hybrid material was determined to be enhanced up to about 95 % in simulated gastric solution (see figure; AEA=polyvinylacetal diethylamino acetate). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | * |
dc.language | English | * |
dc.title | Aripiprazole-montmorillonite: A new organic-inorganic nanohybrid material for biomedical applications | * |
dc.type | Article | * |
dc.relation.issue | 15 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4869 | * |
dc.relation.lastpage | 4875 | * |
dc.relation.journaltitle | Chemistry - A European Journal | * |
dc.identifier.doi | 10.1002/chem.201203384 | * |
dc.identifier.wosid | WOS:000317398300026 | * |
dc.identifier.scopusid | 2-s2.0-84875828708 | * |
dc.author.google | Oh Y.-J. | * |
dc.author.google | Choi G. | * |
dc.author.google | Choy Y.B. | * |
dc.author.google | Park J.W. | * |
dc.author.google | Park J.H. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Yoon Y.J. | * |
dc.author.google | Chang H.C. | * |
dc.author.google | Choy J.-H. | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.contributor.scopusid | 윤여준(7402126465) | * |
dc.contributor.scopusid | 최진호(8044393000) | * |
dc.date.modifydate | 20240405124244 | * |