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dc.contributor.author이수영-
dc.date.accessioned2016-08-28T10:08:44Z-
dc.date.available2016-08-28T10:08:44Z-
dc.date.issued2013-
dc.identifier.issn1001-0602-
dc.identifier.otherOAK-9946-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223600-
dc.description.abstractThe receptor activator of NF-κB (RANK) and immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors are essential factors involved in regulating osteoclast formation and bone remodeling. Here, we identify early estrogen-induced gene 1 (EEIG1) as a novel RANK ligand (RANKL)-inducible protein that physically interacts with RANK and further associates with Gab2, PLCγ2 and Tec/Btk kinases upon RANKL stimulation. EEIG1 positively regulates RANKL-induced osteoclast formation, likely due to its ability to facilitate RANKL-stimulated PLCγ2 phosphorylation and NFATc1 induction. In addition, an inhibitory peptide designed to block RANK-EEIG1 interaction inhibited RANKL-induced bone destruction by reducing osteoclast formation. Together, our results identify EEIG1 as a novel RANK signaling component controlling RANK-mediated osteoclast formation, and suggest that targeting EEIG1 might represent a new therapeutic strategy for the treatment of pathological bone resorption. © 2013 IBCB, SIBS, CAS All rights reserved.-
dc.languageEnglish-
dc.titleEarly estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume23-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage524-
dc.relation.lastpage536-
dc.relation.journaltitleCell Research-
dc.identifier.doi10.1038/cr.2013.33-
dc.identifier.wosidWOS:000316941500011-
dc.identifier.scopusid2-s2.0-84876406009-
dc.author.googleChoi H.K.-
dc.author.googleKang H.R.-
dc.author.googleJung E.-
dc.author.googleKim T.E.-
dc.author.googleLin J.J.-
dc.author.googleLee S.Y.-
dc.contributor.scopusid이수영(53980218900;7409697278)-
dc.date.modifydate20220119154601-
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자연과학대학 > 생명과학전공 > Journal papers
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