Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T10:08:44Z | - |
dc.date.available | 2016-08-28T10:08:44Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1001-0602 | * |
dc.identifier.other | OAK-9946 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223600 | - |
dc.description.abstract | The receptor activator of NF-κB (RANK) and immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors are essential factors involved in regulating osteoclast formation and bone remodeling. Here, we identify early estrogen-induced gene 1 (EEIG1) as a novel RANK ligand (RANKL)-inducible protein that physically interacts with RANK and further associates with Gab2, PLCγ2 and Tec/Btk kinases upon RANKL stimulation. EEIG1 positively regulates RANKL-induced osteoclast formation, likely due to its ability to facilitate RANKL-stimulated PLCγ2 phosphorylation and NFATc1 induction. In addition, an inhibitory peptide designed to block RANK-EEIG1 interaction inhibited RANKL-induced bone destruction by reducing osteoclast formation. Together, our results identify EEIG1 as a novel RANK signaling component controlling RANK-mediated osteoclast formation, and suggest that targeting EEIG1 might represent a new therapeutic strategy for the treatment of pathological bone resorption. © 2013 IBCB, SIBS, CAS All rights reserved. | * |
dc.language | English | * |
dc.title | Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 524 | * |
dc.relation.lastpage | 536 | * |
dc.relation.journaltitle | Cell Research | * |
dc.identifier.doi | 10.1038/cr.2013.33 | * |
dc.identifier.wosid | WOS:000316941500011 | * |
dc.identifier.scopusid | 2-s2.0-84876406009 | * |
dc.author.google | Choi H.K. | * |
dc.author.google | Kang H.R. | * |
dc.author.google | Jung E. | * |
dc.author.google | Kim T.E. | * |
dc.author.google | Lin J.J. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |