DSpace at EWHA: Synthesis and inhibition effects on 5-HT6 receptor of benzothiazole derivatives

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DC Field	Value	Language
dc.contributor.author	박혜영	-
dc.date.accessioned	2016-08-28T10:08:38Z	-
dc.date.available	2016-08-28T10:08:38Z	-
dc.date.issued	2013	-
dc.identifier.issn	0253-2964	-
dc.identifier.other	OAK-9884	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/223543	-
dc.description.abstract	A novel series of aryl sulfonylpiperazine derivatives (5-15) were synthesized as 5-HT6 ligands. In vitro assay was evaluated by measuring the 5-HT-induced Ca2+ increases using HeLa cell line expressing the cloned human 5-HT6 receptor, and the compound 13 showed potent 5-HT6 receptor antagonistic effect with IC50 value of 3.9 μM. Compound 13 also showed good selectivity on the 5-HT6 over 5-HT4 and 5-HT7 receptors.	-
dc.language	English	-
dc.title	Synthesis and inhibition effects on 5-HT6 receptor of benzothiazole derivatives	-
dc.type	Article	-
dc.relation.issue	2	-
dc.relation.volume	34	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.index	KCI	-
dc.relation.startpage	495	-
dc.relation.lastpage	499	-
dc.relation.journaltitle	Bulletin of the Korean Chemical Society	-
dc.identifier.doi	10.5012/bkcs.2013.34.2.495	-
dc.identifier.wosid	WOS:000316430200031	-
dc.identifier.scopusid	2-s2.0-84874525087	-
dc.author.google	Hayat F.	-
dc.author.google	Yoo E.	-
dc.author.google	Rhim H.	-
dc.author.google	Choo H.-Y.P.	-
dc.contributor.scopusid	박혜영(34972649500;57200273796)	-
dc.date.modifydate	20230411110509	-