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dc.contributor.author김태헌-
dc.date.accessioned2016-08-28T10:08:36Z-
dc.date.available2016-08-28T10:08:36Z-
dc.date.issued2013-
dc.identifier.issn1976-2283-
dc.identifier.otherOAK-9869-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223529-
dc.description.abstractBackground/Aims: Genotype C is the principal type of hepatitis B virus (HBV) in Koreans and is associated with poor prognosis for peginterferon ?-2a therapy. The efficacy of and compliance to peginterferon ?-2a therapy were investigated in Koreans with hepatitis B in a real clinical setting. Methods: Hepatitis B patients treated with peginterferon ?-2a from 2008 to 2011 at four university hospitals were consecutively enrolled. Results: Eighty-eight patients were enrolled; 67 were hepatitis B e antigen (HBeAg)-positive. The mean treatment period was 36.1±15.2 weeks. In 26.1% of patients, treatment was discontinued due to insufficient antiviral effects and adverse events. At 24 weeks after treatment, 10/42 (23.8%) HBeAg-positive patients achieved both HBV DNA suppression to <2,000 IU/mL and HBeAg loss/seroconversion. For HBeAg-negative patients, 10/13 (76.9%) achieved HBV DNA suppression to <2,000 IU/mL at 24 weeks after treatment. During the follow-up period, 15 (30.6%) of the 49 patients who achieved HBV DNA suppression to 2,000 IU/mL developed a breakthrough HBV DNA level of >2×106 IU/mL. Conclusions: Peginterferon ?-2a therapy in Koreans with hepatitis B in a real clinical setting resulted in a lower virologic response, as compared to Western individuals, but a favorable durability. There is a need to reduce the high rate of premature discontinuation compared to the controlled studies.-
dc.languageEnglish-
dc.titleThe efficacy and safety of peginterferon-α-2a in Korean patients with chronic hepatitis B: A multicenter study conducted in a real clinical setting-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume7-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage197-
dc.relation.lastpage205-
dc.relation.journaltitleGut and Liver-
dc.identifier.doi10.5009/gnl.2013.7.2.197-
dc.identifier.wosidWOS:000316304300010-
dc.identifier.scopusid2-s2.0-84875113234-
dc.author.googleKwon J.H.-
dc.author.googleKim Y.S.-
dc.author.googleKim S.G.-
dc.author.googleJang J.W.-
dc.author.googleKim T.H.-
dc.author.googleJung Y.K.-
dc.author.googleKwon O.S.-
dc.contributor.scopusid김태헌(57125156300;57219781484)-
dc.date.modifydate20220126130238-
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의과대학 > 의학과 > Journal papers
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