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dc.contributor.author김용재-
dc.date.accessioned2016-08-28T10:08:36Z-
dc.date.available2016-08-28T10:08:36Z-
dc.date.issued2013-
dc.identifier.issn1351-5101-
dc.identifier.otherOAK-9865-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223526-
dc.description.abstractBackground and purpose: Pre-existing brain infarct (PBI), frequently seen on magnetic resonance imaging and usually silent, is recognized as a risk factor for future stroke. Increased apolipoprotein B (apoB)/apoAI ratio is known to be a risk predictor of ischaemic stroke and is associated with intracranial atherosclerotic stenosis (ICAS). However, little is known about the association of apoB/apoAI ratio with PBI. Methods: A total of 522 statin-/fibrate-naïve Korean patients, who experienced acute ischaemic stroke, were categorized into three groups: ICAS (n = 254), extracranial (n = 51), and no cerebral atherosclerotic stenosis (n = 217). We explored the association between apoB/apoAI ratio and PBI lesions according to atherosclerosis type (ICAS, ECAS, and NCAS), PBI location (deep subcortical [ds-PBI] versus hemispheric [h-PBI]), and symptomatic PBI (s-PBI) which was relevant to a prior clinical stroke event. Results: Pre-existing brain infarct(+) patients showed a higher apoB/apoAI ratio than PBI(-) patients (0.81 ± 0.28 vs. 0.72 ± 0.23, P < 0.001). In ICAS group, patients with higher apoB/apoAI ratio quartiles had more PBIs, ds-PBIs, and s-PBIs (P = 0.020, P = 0.025, and P = 0.001, respectively). With multivariable analyses, the highest apoB/apoAI ratio quartile was associated with PBI (OR, 2.56; 95% CI, 1.39-4.73), ds-PBI (2.48; 1.33-4.62), and advanced (≥3) ds-PBIs (2.68; 1.27-5.63) in ICAS group, but not with h-PBI. s-PBI had a dose-response relationship with apoB/apoAI ratio quartiles (6.18; 1.31-29.13 for the second; 5.34; 1.06-26.83 for the third; and 12.17; 2.50-59.19 for the fourth quartile), when referenced to the first quartile. Conclusion: ApoB/apoAI ratio is associated with asymptomatic deep subcortical ischaemic burden as well as with symptomatic lesion in patients with ICAS. © 2012 The Author(s). European Journal of Neurology © 2012 EFNS.-
dc.languageEnglish-
dc.titleDeep subcortical infarct burden in relation to apolipoprotein B/AI ratio in patients with intracranial atherosclerotic stenosis-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume20-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage671-
dc.relation.lastpage680-
dc.relation.journaltitleEuropean Journal of Neurology-
dc.identifier.doi10.1111/ene.12021-
dc.identifier.wosidWOS:000316258800018-
dc.identifier.scopusid2-s2.0-84875036750-
dc.author.googlePark J.-H.-
dc.author.googleHong K.-S.-
dc.author.googleLee J.-
dc.author.googleKim Y.-J.-
dc.author.googleSong P.-
dc.contributor.scopusid김용재(36910759200)-
dc.date.modifydate20190301081000-
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의과대학 > 의학과 > Journal papers
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