Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최규복 | - |
dc.date.accessioned | 2016-08-28T10:08:30Z | - |
dc.date.available | 2016-08-28T10:08:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.other | OAK-9801 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223470 | - |
dc.description.abstract | Purpose: Cinacalcet is effective for treating refractory secondary hyperparathyroidism (SHPT), but little is known about the response rates and clinical factors influencing the response. Materials and Methods: A prospective, single-arm, multi-center study was performed for 24 weeks. Cinacalcet was administered to patients with intact parathyroid hormone (iPTH) level greater than 300 pg/mL. Cinacalcet was started at a dose of 25 mg daily and titrated until 100 mg to achieve a serum iPTH level <300 pg/mL (primary end point). Early response to cinacalcet was defined as a decrease of iPTH more than 50% within one month. Results: Fifty-seven patients were examined. Based on the magnitude of iPTH decrease, patients were divided into responder (n=47, 82.5%) and non-responder (n=10, 17.5%) groups. Among the responders, 38 achieved the primary end point, whereas 9 patients showed a reduction in serum iPTH of 30% or more, but did not reach the primary end point. Compared to non-responders, responders were significantly older (p=0.026), female (p=0.041), and diabetics (p<0.001). Additionally, early response was observed more frequently in the responders (30/47, 63.8%), of whom the majority (27/30, 90.0%) achieved the primary end point. Multivariate analysis showed that lower baseline iPTH levels [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.93-0.99], the presence of diabetes (OR 46.45, CI 1.92-1125.6) and early response (OR 21.54, CI 2.94-157.7) were significant clinical factors affecting achievement of iPTH target. Conclusion: Cinacalcet was effective in most hemodialysis patients with refractory SHPT. The presence of an early response was closely associated with the achievement of target levels of iPTH. © Yonsei University College of Medicine 2013. | - |
dc.language | English | - |
dc.title | Rapid decrease of intact parathyroid hormone could be a predictor of better response to cinacalcet in hemodialysis patients | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 54 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 453 | - |
dc.relation.lastpage | 463 | - |
dc.relation.journaltitle | Yonsei Medical Journal | - |
dc.identifier.doi | 10.3349/ymj.2013.54.2.453 | - |
dc.identifier.wosid | WOS:000315540600026 | - |
dc.identifier.scopusid | 2-s2.0-84873272867 | - |
dc.author.google | Kim J.-K. | - |
dc.author.google | Kwon Y.J. | - |
dc.author.google | Kim S.W. | - |
dc.author.google | Kim Y.-H. | - |
dc.author.google | Park C.W. | - |
dc.author.google | Choi K.B. | - |
dc.author.google | Hwang S.D. | - |
dc.author.google | Choi K.H. | - |
dc.contributor.scopusid | 최규복(36096388100) | - |
dc.date.modifydate | 20230703145716 | - |