Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최진호 | - |
dc.contributor.author | 양재훈 | - |
dc.date.accessioned | 2016-08-28T10:08:28Z | - |
dc.date.available | 2016-08-28T10:08:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.other | OAK-9778 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223448 | - |
dc.description.abstract | For transdermal drug delivery, we prepared a drug-inorganic nanohybrid (FB-LDH) by intercalating a transdermal model drug, flurbiprofen (FB), into the layered double hydroxides (LDHs) via coprecipitation reaction. The X-ray diffraction patterns and FT-IR spectra of the FB-LDH indicated that the FB molecules were successfully intercalated via electrostatic interaction within the LDH lattices. The in vitro drug release revealed that the Eudragit® S-100 in release media could facilitate the drug out-diffusion by effectively replacing the intercalated drug and also enlarging the lattice spacing of the FB-LDH. In this work, a hydrophobic gel suspension of the FB-LDH was suggested as a transdermal controlled delivery formulation, where the suspensions were mixed with varying amounts of Eudragit® S-100 aqueous solution. The Frantz diffusion cell experiments using mouse full-skins showed that a lag time and steady-state flux of the drug could be controlled from 12.8 h and 3.28 μg cm-2 h-1 to less than 1 h and 14.57 μg cm-2 h-1, respectively, by increasing the mass fraction of Eudragit® S-100 solution in gel suspensions from 0% to 20% (w/w), respectively. Therefore, we conclude gel formulation of the FB-LDH have a potential for transdermal controlled drug delivery. © 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Drug-inorganic-polymer nanohybrid for transdermal delivery | - |
dc.type | Article | - |
dc.relation.issue | 41276 | - |
dc.relation.volume | 444 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 120 | - |
dc.relation.lastpage | 127 | - |
dc.relation.journaltitle | International Journal of Pharmaceutics | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.12.043 | - |
dc.identifier.wosid | WOS:000315298700016 | - |
dc.identifier.scopusid | 2-s2.0-84873714859 | - |
dc.author.google | Kim M.H. | - |
dc.author.google | Park D.-H. | - |
dc.author.google | Yang J.-H. | - |
dc.author.google | Choy Y.B. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.contributor.scopusid | 양재훈(57157748500) | - |
dc.date.modifydate | 20190301081000 | - |