Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 이혁우 | - |
dc.date.accessioned | 2016-08-28T10:08:25Z | - |
dc.date.available | 2016-08-28T10:08:25Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | OAK-9742 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223414 | - |
dc.description.abstract | Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII). Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia cells to TGF-β. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while preventing its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation. We have also identified a neddylation-activity-defective c-Cbl mutation from leukemia patients, implying a link between aberrant TβRII neddylation and leukemia development. © 2013 Elsevier Inc. | - |
dc.language | English | - |
dc.title | C-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 49 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 499 | - |
dc.relation.lastpage | 510 | - |
dc.relation.journaltitle | Molecular Cell | - |
dc.identifier.doi | 10.1016/j.molcel.2012.12.002 | - |
dc.identifier.wosid | WOS:000314792500013 | - |
dc.identifier.scopusid | 2-s2.0-84873438391 | - |
dc.author.google | Zuo W. | - |
dc.author.google | Huang F. | - |
dc.author.google | Chiang Y.J. | - |
dc.author.google | Li M. | - |
dc.author.google | Du J. | - |
dc.author.google | Ding Y. | - |
dc.author.google | Zhang T. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Chen Y. | - |
dc.author.google | Deng H. | - |
dc.author.google | Feng X.-H. | - |
dc.author.google | Luo S. | - |
dc.author.google | Gao C. | - |
dc.author.google | Chen Y.-G. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 이혁우(7501494177) | - |
dc.date.modifydate | 20220112111245 | - |