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dc.contributor.author류재상-
dc.date.accessioned2016-08-28T10:08:24Z-
dc.date.available2016-08-28T10:08:24Z-
dc.date.issued2013-
dc.identifier.issn0960-894X-
dc.identifier.otherOAK-9725-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223401-
dc.description.abstractA series of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles has been synthesized and evaluated for their ALK5 inhibitory activity. The 1-(6-methylpyridin-2-yl)-1,2,3-triazoles were assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition. Following this, quinoxaline was introduced through Pd-catalyzed direct arylation. The synthesized 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles revealed significant selectivity differences with respect to p38α MAP kinase. In particular, 12k showed 80.8% ALK5 inhibitory activity at a concentration of 10 μM and IC50 value of 4.69 μM, but did not show p38α MAP kinase inhibitory activity (-1.94% inhibition at a concentration of 10 μM). © 2012 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleSynthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5- (quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-β type 1 receptor kinase inhibitors-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume23-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1083-
dc.relation.lastpage1086-
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters-
dc.identifier.doi10.1016/j.bmcl.2012.12.008-
dc.identifier.wosidWOS:000314625400032-
dc.identifier.scopusid2-s2.0-84872939277-
dc.author.googleLi F.-
dc.author.googlePark Y.-
dc.author.googleHah J.-M.-
dc.author.googleRyu J.-S.-
dc.contributor.scopusid류재상(36081118200)-
dc.date.modifydate20180104081001-
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약학대학 > 약학과 > Journal papers
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