Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최선 | * |
dc.date.accessioned | 2016-08-28T10:08:21Z | - |
dc.date.available | 2016-08-28T10:08:21Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1861-4728 | * |
dc.identifier.other | OAK-9694 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223373 | - |
dc.description.abstract | A series of heterocycle-linked constrained phenylbenzyl amides were found to be TRPV1 antagonists with promising in vivo profiles. In particular, one of the analogues containing a furan linker exhibited excellent TRPV1 antagonistic activity and in vivo analgesic efficacy. In addition, the binding modes of dibenzyl thiourea, benzylphenethyl amide, and furan-linked phenylbenzyl amide were examined by using the flexible docking study within the rTRPV1 homology model. Flexibility not desired: A series of heterocycle-linked constrained phenylbenzyl amides were found to be TRPV1 antagonists with promising in vivo profiles. In particular, one of the analogues containing a furan linker exhibited excellent TRPV1 antagonistic activity and in vivo analgesic efficacy. In addition, the binding modes of dibenzyl thiourea, benzylphenethyl amide, and furan-linked phenylbenzyl amide were examined by using the flexible docking study within the rTRPV1 homology model. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | * |
dc.language | English | * |
dc.title | Heterocycle-linked phenylbenzyl amides as novel TRPV1 antagonists and their TRPV1 binding modes: Constraint-induced enhancement of in vitro and in vivo activities | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 400 | * |
dc.relation.lastpage | 409 | * |
dc.relation.journaltitle | Chemistry - An Asian Journal | * |
dc.identifier.doi | 10.1002/asia.201200730 | * |
dc.identifier.wosid | WOS:000314177300012 | * |
dc.identifier.scopusid | 2-s2.0-84873842620 | * |
dc.author.google | Kim N.-J. | * |
dc.author.google | Li F.-N. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Park S.-G. | * |
dc.author.google | Kim K. | * |
dc.author.google | Lim C. | * |
dc.author.google | Han Y.T. | * |
dc.author.google | Yun H. | * |
dc.author.google | Jung J.-W. | * |
dc.author.google | Park H.-G. | * |
dc.author.google | Kim H.-D. | * |
dc.author.google | Woo B.Y. | * |
dc.author.google | Shin S.S. | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Choi J.K. | * |
dc.author.google | Jeong Y.-S. | * |
dc.author.google | Park Y. | * |
dc.author.google | Park Y.-H. | * |
dc.author.google | Kim D.-D. | * |
dc.author.google | Choi S. | * |
dc.author.google | Suh Y.-G. | * |
dc.contributor.scopusid | 최선(8659831000) | * |
dc.date.modifydate | 20240305081003 | * |