Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 정우진 | * |
dc.date.accessioned | 2016-08-28T10:08:18Z | - |
dc.date.available | 2016-08-28T10:08:18Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0022-1767 | * |
dc.identifier.other | OAK-9658 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223349 | - |
dc.description.abstract | NF-kB is one of the key transcription factors activated by receptor activator of NF-kB ligand (RANKL) during osteoclast differentiation. The 8-kDa dynein L chain (LC8) was previously identified as a novel NF-kB regulator. However, its physiological role as an NF-kB inhibitor remains elusive. In this study, we showed the inhibitory role of LC8 in RANKL-induced osteoclastogenesis and signaling pathways and its protective role in osteolytic animal models. LC8 suppressed RANKL-induced osteoclast differentiation, actin ring formation, and osteoclastic bone resorption. LC8 inhibited RANKL-induced phosphorylation and subsequent degradation of IkBa, the expression of c-Fos, and the consequent activation of NFATc1, which is a pivotal determinant of osteoclastogenesis. LC8 also inhibited RANKL-induced activation of JNK and ERK. LC8-transgenic mice exhibited a mild osteopetrotic phenotype. Moreover, LC8 inhibited inflammation-induced bone erosion and protected against ovariectomy-induced bone loss in mice. Thus, our results suggest that LC8 inhibits osteoclast differentiation by regulating NF-kB and MAPK pathways and provide the molecular basis of a new strategy for treating osteoporosis and other bone diseases. Copyright © 2013 by The American Association of Immunologists, Inc. | * |
dc.language | English | * |
dc.title | Dynein light chain LC8 inhibits osteoclast differentiation and prevents bone loss in mice | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 190 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1312 | * |
dc.relation.lastpage | 1318 | * |
dc.relation.journaltitle | Journal of Immunology | * |
dc.identifier.doi | 10.4049/jimmunol.1202525 | * |
dc.identifier.wosid | WOS:000313784200049 | * |
dc.identifier.scopusid | 2-s2.0-84872716794 | * |
dc.author.google | Kim H. | * |
dc.author.google | Hyeon S. | * |
dc.author.google | Yang Y. | * |
dc.author.google | Huh J.Y. | * |
dc.author.google | Park D.R. | * |
dc.author.google | Lee H. | * |
dc.author.google | Seo D.-H. | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Jeong W. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 정우진(35914322500) | * |
dc.date.modifydate | 20240415140424 | * |