Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정화순 | * |
dc.contributor.author | 성주명 | * |
dc.contributor.author | 허정원 | * |
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2016-08-28T10:08:14Z | - |
dc.date.available | 2016-08-28T10:08:14Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0001-5792 | * |
dc.identifier.other | OAK-9603 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223303 | - |
dc.description.abstract | The clinical heterogeneity of patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) with trisomy 8 as the sole abnormality may result from cytogenetically undetectable genetic changes. The purpose of this study was to identify hidden genomic aberrations not detected by metaphase cytogenetics (MC) using high-resolution single nucleotide polymorphism array (SNP-A)-based karyotyping in AML/MDS patients with a sole trisomy 8. The study group included 8 patients (3 AML and 5 MDS) and array-based karyotyping was done using whole-genome SNP-A (SNP 6.0 and SNP 2.7M). By SNP-A, additional genomic aberrations not detected by MC were identified in 2 patients: 1 AML patient exhibited a copy-neutral loss of heterozygosity (CN-LOH) of 3q21.1-q29 and 11q13.1-q25 and the other patient with MDS (refractory cytopenia with unilineage dysplasia) had CN-LOH of 2p25.3-p15. In particular, the latter patient progressed to AML 18 months after the diagnosis. In 3 patients, aberrations in addition to trisomy 8 were not identified by SNP-A. In the remaining 3 patients, SNP-A could not detect trisomy 8, while trisomy 8 was found in 25-67% of metaphase cells by MC. This study suggests that additional genomic aberrations may in fact be present even in cases of trisomy 8 as sole abnormality by MC, and SNP-A could be a useful karyotyping tool to identify hidden aberrations such as CN-LOH. Copyright © 2012 S. Karger AG, Basel. | * |
dc.language | English | * |
dc.title | Single nucleotide polymorphism array-based karyotyping in acute myeloid leukemia or myelodysplastic syndrome with trisomy 8 as the sole chromosomal abnormality | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 129 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 154 | * |
dc.relation.lastpage | 158 | * |
dc.relation.journaltitle | Acta Haematologica | * |
dc.identifier.doi | 10.1159/000343420 | * |
dc.identifier.wosid | WOS:000312900600004 | * |
dc.identifier.scopusid | 2-s2.0-84870291646 | * |
dc.author.google | Hahm C. | * |
dc.author.google | Mun Y.C. | * |
dc.author.google | Seong C.M. | * |
dc.author.google | Han S.-H. | * |
dc.author.google | Chung W.S. | * |
dc.author.google | Huh J. | * |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | * |
dc.contributor.scopusid | 성주명(7005537065) | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |