Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지은 | * |
dc.contributor.author | 류인균 | * |
dc.date.accessioned | 2016-08-28T10:08:06Z | - |
dc.date.available | 2016-08-28T10:08:06Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0003-990X | * |
dc.identifier.other | OAK-9513 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223228 | - |
dc.description.abstract | Context: Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated. Objective: To investigate neuroanatomic correlates of depression in T1DM. Design: Case-control study using high-resolution brain magnetic resonance images. Settings: Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea. Participants: A total of 125 patients with T1DM (44 subjects with ≥1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group). Main Outcome Measures: Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined. Results: Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P<.01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (β=-0.19, P=.02). Conclusions: This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression. ©2012 American Medical Association. All rights reserved. | * |
dc.language | English | * |
dc.title | Prefrontal cortical deficits in type 1 diabetes mellitus: Brain correlates of comorbid depression | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 69 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1267 | * |
dc.relation.lastpage | 1276 | * |
dc.relation.journaltitle | Archives of General Psychiatry | * |
dc.identifier.doi | 10.1001/archgenpsychiatry.2012.543 | * |
dc.identifier.wosid | WOS:000311804500009 | * |
dc.identifier.scopusid | 2-s2.0-84870626646 | * |
dc.author.google | Lyoo I.K. | * |
dc.author.google | Yoon S. | * |
dc.author.google | Jacobson A.M. | * |
dc.author.google | Hwang J. | * |
dc.author.google | Musen G. | * |
dc.author.google | Kim J.E. | * |
dc.author.google | Simonson D.C. | * |
dc.author.google | Bae S. | * |
dc.author.google | Bolo N. | * |
dc.author.google | Kim D.J. | * |
dc.author.google | Weinger K. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Ryan C.M. | * |
dc.author.google | Renshaw P.F. | * |
dc.contributor.scopusid | 김지은(55353332200) | * |
dc.contributor.scopusid | 류인균(55664289900) | * |
dc.date.modifydate | 20240220114752 | * |