Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 우소연 | * |
dc.contributor.author | 조경아 | * |
dc.date.accessioned | 2016-08-28T10:08:04Z | - |
dc.date.available | 2016-08-28T10:08:04Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1013-9087 | * |
dc.identifier.other | OAK-9483 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223204 | - |
dc.description.abstract | The pathogenesis of psoriasis may involve the interleukin (IL)-23 and Th17-mediated immune responses. Th17 cells secret IL-17 and IL-22, which mediates dermal inflammation and acanthosis. Objective: As inhibitor of nuclear factor ?B kinase-a (IKKa) has been previously identified as a primary regulator of keratinocyte differentiation and proliferation, we proposed that IL-17 and IL-22 might affect keratinocyte differentiation by changing the expression of IKKa. Methods: We employed HaCaT cells maintained culture medium at a low calcium concentration (0.06 mM) and induced differentiation by switching to the high concentration (2.8 mM) media with IL-17 or IL-22, then compared the IKKa expression and the cell cycle. We employed reconstituted human epidermal skin (Neoderm) and mice ears for the in vivo studies. Results: Elevated calcium concentration induced IKKa expression and terminal differentiation with cell cycle arrest in HaCaT cell cultures. Moreover, IL-17 and IL-22 treatment also induced IKKa in HaCaT cells and reconstituted human epidermis. IKKa induction was also noted, following the injection of IL-17 and IL-22 into mice ears. Conclusion: Although the induction of IKKa was accompanied by keratinocyte differentiation, IL-17 and IL-22 did not affect calcium-mediated differentiation or the cell cycle. Rather, IL-17 and IL-22 appear to contribute to the inflammation occurring via the induction of IKKa from keratinocytes or skin layers. | * |
dc.language | English | * |
dc.title | Interleukin-17 and interleukin-22 induced proinflammatory cytokine production in keratinocytes via inhibitor of nuclear factor-b kinase-a expression | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 398 | * |
dc.relation.lastpage | 405 | * |
dc.relation.journaltitle | Annals of Dermatology | * |
dc.identifier.doi | 10.5021/ad.2012.24.4.398 | * |
dc.identifier.wosid | WOS:000311462400003 | * |
dc.identifier.scopusid | 2-s2.0-84870813363 | * |
dc.author.google | Cho K.-A. | * |
dc.author.google | Kim J.-Y. | * |
dc.author.google | Woo S.-Y. | * |
dc.author.google | Park H.J. | * |
dc.author.google | Lee K.H. | * |
dc.author.google | Pae C.-U. | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.date.modifydate | 20240222161025 | * |