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신산업융합대학
의류산업학과
Journal papers
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Induction of classical activation of macrophage in vitro by water soluble chitin
Title
Induction of classical activation of macrophage in vitro by water soluble chitin
Authors
Jeon D.-W.
;
Ahn W.S.
;
You S.J.
;
Chae G.T.
;
Shim Y.B.
;
Chun H.J.
Ewha Authors
전동원
SCOPUS Author ID
전동원
Issue Date
2012
Journal Title
Applied Surface Science
ISSN
0169-4332
Citation
Applied Surface Science vol. 262, pp. 134 - 139
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
The purpose of this study is to understand the effect of chitin on macrophage mediated immunity, which is a significant factor to wound healing and tissue regeneration. In this work, water soluble chitin (WSC) was prepared by re-acetylation of chitosan and was treated with the murine RAW 264.7 macrophage cell lines (ATCC TIB-71). WSC induced classical activation in the RAW 264.7 cells, accompanied by the induction of associated genes. The results suggest that WSC is one of the functional chitin molecules that are responsible for the immune response, especially present in macrophage classical activation. © 2012 Elsevier B.V. All rights reserved.
DOI
10.1016/j.apsusc.2012.03.078
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