Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형래 | * |
dc.contributor.author | 성연아 | * |
dc.contributor.author | 이혜진 | * |
dc.date.accessioned | 2016-08-28T10:08:58Z | - |
dc.date.available | 2016-08-28T10:08:58Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1434-5161 | * |
dc.identifier.other | OAK-9363 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223130 | - |
dc.description.abstract | To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n482) and in a gestational diabetes study (n1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation. © 2012 The Japan Society of Human Genetics All rights reserved. | * |
dc.language | English | * |
dc.title | Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 660 | * |
dc.relation.lastpage | 664 | * |
dc.relation.journaltitle | Journal of Human Genetics | * |
dc.identifier.doi | 10.1038/jhg.2012.92 | * |
dc.identifier.wosid | WOS:000310526500007 | * |
dc.identifier.scopusid | 2-s2.0-84867921300 | * |
dc.author.google | Hwang J.-Y. | * |
dc.author.google | Lee E.-J. | * |
dc.author.google | Jin Go M. | * |
dc.author.google | Sung Y.-A. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Heon Kwak S. | * |
dc.author.google | Jang H.C. | * |
dc.author.google | Soo Park K. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Byul Jang H. | * |
dc.author.google | Song J. | * |
dc.author.google | Park K.-H. | * |
dc.author.google | Kim H.-L. | * |
dc.author.google | Cho M.-C. | * |
dc.author.google | Lee J.-Y. | * |
dc.contributor.scopusid | 김형래(57202558385;57219111690;57567109600) | * |
dc.contributor.scopusid | 성연아(18435369300) | * |
dc.contributor.scopusid | 이혜진(56192810300) | * |
dc.date.modifydate | 20240123102249 | * |