View : 684 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author김형래*
dc.contributor.author성연아*
dc.contributor.author이혜진*
dc.date.accessioned2016-08-28T10:08:58Z-
dc.date.available2016-08-28T10:08:58Z-
dc.date.issued2012*
dc.identifier.issn1434-5161*
dc.identifier.otherOAK-9363*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223130-
dc.description.abstractTo investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n482) and in a gestational diabetes study (n1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation. © 2012 The Japan Society of Human Genetics All rights reserved.*
dc.languageEnglish*
dc.titleGenome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition*
dc.typeArticle*
dc.relation.issue10*
dc.relation.volume57*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage660*
dc.relation.lastpage664*
dc.relation.journaltitleJournal of Human Genetics*
dc.identifier.doi10.1038/jhg.2012.92*
dc.identifier.wosidWOS:000310526500007*
dc.identifier.scopusid2-s2.0-84867921300*
dc.author.googleHwang J.-Y.*
dc.author.googleLee E.-J.*
dc.author.googleJin Go M.*
dc.author.googleSung Y.-A.*
dc.author.googleLee H.J.*
dc.author.googleHeon Kwak S.*
dc.author.googleJang H.C.*
dc.author.googleSoo Park K.*
dc.author.googleLee H.-J.*
dc.author.googleByul Jang H.*
dc.author.googleSong J.*
dc.author.googlePark K.-H.*
dc.author.googleKim H.-L.*
dc.author.googleCho M.-C.*
dc.author.googleLee J.-Y.*
dc.contributor.scopusid김형래(57202558385;57219111690;57567109600)*
dc.contributor.scopusid성연아(18435369300)*
dc.contributor.scopusid이혜진(56192810300)*
dc.date.modifydate20240123102249*
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE