View : 310 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author이승진-
dc.contributor.author심인경-
dc.date.accessioned2016-08-28T10:08:57Z-
dc.date.available2016-08-28T10:08:57Z-
dc.date.issued2012-
dc.identifier.issn0168-3659-
dc.identifier.otherOAK-9362-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223129-
dc.description.abstractThe use of tissue engineering to repair large osteochondral defects has been impeded by the limited regenerative capacity of cartilage. Herein, we describe the local release of bone morphogenetic protein 7 (BMP-7) to stimulate the bone marrow-derived progenitors to repair osteochondral defects. BMP-7-releasing poly(d,l-lactide-co-glycolide) (PLGA) matrix was specially designed to retain the dual-function of local BMP-7 release and progenitor-scaffolding with its defect-fitting architecture. To optimize the release kinetics during the repair period, BMP-7/PLGA film was cast on the surface of a cylindrical PLGA matrix. The matrix demonstrated a release profile of BMP-7 in a sustained manner over 28 days, maintaining its biological activity. The cylindrical PLGA matrices loaded with BMP-7 were implanted into the osteochondral defects (2 mm in diameter, 3 mm in depth) in rabbit knees. Histological observations revealed that neo-cartilage generation was completed in a well-integrated morphology with its surrounding normal cartilage and subchondral bone at 12 weeks post-implantation. Partial degradation of the PLGA matrix during the repair period guided neo-cartilage formation, which verified the effective scaffolding function of the matrix. Regenerated cartilage in BMP-7-treated defects stained positive for type II collagen and glycosaminoglycan (GAG). Adjacent BMP-7-untreated defects were also repaired with cartilage regeneration, suggesting the effect of local BMP-7 release in the synovial fluid. The BMP-7-unloaded PLGA matrix demonstrated guided cartilage regeneration to a certain extent, whereas the adjacent defects without the matrix revealed only fibrous tissue infiltration. These results indicated that a strategy employing the combined functions of local BMP-7 release and the cell scaffolding of a PLGA matrix might be a potential modality for osteochondral repair. © 2012 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.titleLocal BMP-7 release from a PLGA scaffolding-matrix for the repair of osteochondral defects in rabbits-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume162-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage485-
dc.relation.lastpage491-
dc.relation.journaltitleJournal of Controlled Release-
dc.identifier.doi10.1016/j.jconrel.2012.07.040-
dc.identifier.wosidWOS:000310506900002-
dc.identifier.scopusid2-s2.0-84865589117-
dc.author.googleJung M.R.-
dc.author.googleShim I.K.-
dc.author.googleChung H.J.-
dc.author.googleLee H.R.-
dc.author.googlePark Y.J.-
dc.author.googleLee M.C.-
dc.author.googleYang Y.I.-
dc.author.googleDo S.H.-
dc.author.googleLee S.J.-
dc.contributor.scopusid이승진(57196249292;12545448000)-
dc.date.modifydate20220119153635-
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE