Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이서구 | * |
dc.contributor.author | 배수한 | * |
dc.contributor.author | 길인섭 | * |
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2016-08-28T10:08:45Z | - |
dc.date.available | 2016-08-28T10:08:45Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1523-0864 | * |
dc.identifier.other | OAK-9219 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223010 | - |
dc.description.abstract | Aims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress. Results: Pyrazole increased Srx expression in the liver of mice in a nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent manner and induced Srx translocation from the cytosol to the endoplasmic reticulum (ER) and mitochondria. Pyrazole also induced the expression of CYP2E1, a primary reactive oxygen species (ROS) source for ethanol-induced liver injury, in ER and mitochondria. However, increased CYP2E1 levels only partially accounted for the pyrazole-mediated induction of Srx, prompting the investigation of CYP2E1-independent ROS generation downstream of pyrazole. Indeed, pyrazole increased ER stress, which is known to elevate mitochondrial ROS. In addition, pyrazole upregulated CYP2E1 to a greater extent in mitochondria than in ER. Accordingly, among Prxs I to IV, PrxIII, which is localized to mitochondria, was preferentially hyperoxidized in the liver of pyrazole-treated mice. Pyrazoleinduced oxidative damage to the liver was greater in PrxIII -/- mice than in wild-type mice. Such damage was also increased in Srx -/- mice treated with pyrazole, underscoring the role of Srx as the guardian of PrxIII. Innovation: The roles of Prxs, Srx, and ER stress have not been previously studied in relation to pyrazole toxicity. Conclusion: The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. © 2012 Mary Ann Liebert, Inc. | * |
dc.language | English | * |
dc.title | Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1351 | * |
dc.relation.lastpage | 1361 | * |
dc.relation.journaltitle | Antioxidants and Redox Signaling | * |
dc.identifier.doi | 10.1089/ars.2011.4334 | * |
dc.identifier.wosid | WOS:000308804200002 | * |
dc.identifier.scopusid | 2-s2.0-84866286088 | * |
dc.author.google | Bae S.H. | * |
dc.author.google | Sung S.H. | * |
dc.author.google | Lee H.E. | * |
dc.author.google | Kang H.T. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Oh S.Y. | * |
dc.author.google | Woo H.A. | * |
dc.author.google | Kil I.S. | * |
dc.author.google | Rhee S.G. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.contributor.scopusid | 길인섭(152039) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240423081003 | * |