Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최진호 | - |
dc.date.accessioned | 2016-08-28T10:08:42Z | - |
dc.date.available | 2016-08-28T10:08:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0002-7820 | - |
dc.identifier.other | OAK-9164 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222971 | - |
dc.description.abstract | The anticancer drug methotrexate (MTX) was successfully incorporated into the layered ceramic nanoparticles of layered double hydroxides (LDHs). The prepared MTX-LDH two-dimensional nanoassemblies showed enhanced chemical and thermal stability of intercalated MTX molecules through the effective electrostatic interaction with ceramic LDH layers. And the surface charge of MTX-LDHs was determined to be highly positive whereas that of MTX is fairly negative. The anticancer effect of MTX-LDH compared with MTX was evaluated in the human osteosarcoma cell culture line SaOS-2, showing much faster drug efficacy with low concentration. The time-dependent cellular uptake of MTX determined by high performance liquid chromatography showed the much enhanced cellular drug concentration of MTX-LDH treated cancer cells than the MTX treated ones. The particle size of MTX-LDH nanoassemblies was estimated in various solutions such as saline, phosphate saline, and RPMI 1640 cell culture medium, showing that the hydrodynamic size maintains at ∼100 nm, regardless of the suspension media. The positive surface charge and ∼100 nm size of MTX-LDHs is considered to be the major factor in the high cellular uptake and enhanced drug efficacy. © 2012 The American Ceramic Society. | - |
dc.language | English | - |
dc.title | Drug-ceramic 2-dimensional nanoassemblies for drug delivery system in physiological condition | - |
dc.type | Conference Paper | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 95 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2758 | - |
dc.relation.lastpage | 2765 | - |
dc.relation.journaltitle | Journal of the American Ceramic Society | - |
dc.identifier.doi | 10.1111/j.1551-2916.2012.05219.x | - |
dc.identifier.wosid | WOS:000308290400014 | - |
dc.identifier.scopusid | 2-s2.0-84865725504 | - |
dc.author.google | Choi G. | - |
dc.author.google | Kim S.Y. | - |
dc.author.google | Oh J.-M. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.date.modifydate | 20190301081000 | - |