Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진흥 | - |
dc.date.accessioned | 2016-08-28T10:08:38Z | - |
dc.date.available | 2016-08-28T10:08:38Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1520-6106 | - |
dc.identifier.other | OAK-9108 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222926 | - |
dc.description.abstract | Zn(II) meso-tetrakis(N-methylpyridinium-4-yl)porphyrin (ZnTMPyP) produced a unique linear dichroism (LD) spectrum when forming a complex with Z-form poly[d(G-C)2]. The spectrum was characterized by a large positive wavelength-dependent LD signal in the Soret absorption region. The magnitudes of LD in both the DNA and Soret band increased as the [porphyrin]/[DNA base] ratio increased and were larger by 20-40 times compared to the negative LD of the ZnTMPyP bound to B-form poly[d(G-C)2] and poly[d(A-T)2]. The angles calculated from LD were respectively 49° and 42° for B x and By transitions of the porphyrin with respect to the local helix axis of Z-form poly[d(G-C)2]. The appearance of the unique LD spectrum for the Z-form poly[d(G-C)2] complex was accompanied by a bisignate circular dichroism spectrum in the Soret region, whose magnitude was proportional to the square of the porphyrin concentration, suggesting a stacking interaction between Z-form poly[d(G-C)2]-bound ZnTMPyP with other bound ZnTMPyP. From these observations, a conceivable binding mode of ZnTMPyP to Z-form poly[d(G-C)2] complex was proposed, in which ZnTMPyP binds at the major groove or across the groove. In contrast with Z-form poly[d(G-C)2], ZnTMPyP binds to poly[d(A-T)2] in a monomeric manner with the angles of 57° and 59° for the two porphyrins transition moments with respect to the local polynucleotide helix axis. The polarized spectral properties of ZnTMPyP bound to B-form poly[d(G-C) 2] coincide with the intercalated nonmetallic TMPyP, namely, a negative CD signal in the Soret band and a negative wavelength-dependent reduced LD signal, with a magnitude larger than that in the DNA absorption region in spite of its axial ligands. © 2012 American Chemical Society. | - |
dc.language | English | - |
dc.title | Z-form DNA specific binding geometry of Zn(II) meso -tetrakis(N -methylpyridinium-4-yl)porphyrin probed by linear dichroism spectroscopy | - |
dc.type | Article | - |
dc.relation.issue | 32 | - |
dc.relation.volume | 116 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 9619 | - |
dc.relation.lastpage | 9626 | - |
dc.relation.journaltitle | Journal of Physical Chemistry B | - |
dc.identifier.doi | 10.1021/jp3041346 | - |
dc.identifier.wosid | WOS:000307494500007 | - |
dc.identifier.scopusid | 2-s2.0-84865141196 | - |
dc.author.google | Gong L. | - |
dc.author.google | Jang Y.J. | - |
dc.author.google | Kim J. | - |
dc.author.google | Kim S.K. | - |
dc.contributor.scopusid | 김진흥(8580015800) | - |
dc.date.modifydate | 20230201114415 | - |