Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 유은선 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 박윤신 | * |
dc.date.accessioned | 2016-08-28T10:08:34Z | - |
dc.date.available | 2016-08-28T10:08:34Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-9072 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222891 | - |
dc.description.abstract | Neutropenia is a principal complication of cancer treatment. We investigated the supportive effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) on the viability and function of neutrophils. Neutrophils were derived from HL-60 cells by dimethylformamide stimulation and cultured with or without AD-MSCs under serum-starved conditions to evaluate neutrophil survival, proliferation, and function. Serum starvation resulted in the apoptosis of neutrophils and decreased cell survival. The co-culture of neutrophils and AD-MSCs resulted in cell survival and inhibited neutrophil apoptosis under serum-starved conditions. The survival rate of neutrophils was prolonged up to 72. h, and the expression levels of interferon (IFN)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)-β in AD-MSCs were increased after co-culture with neutrophils. AD-MSCs promoted the viability of neutrophils by inhibiting apoptosis as well as enhancing respiratory burst, which could potentially be mediated by the increased expression of IFN-α, G-CSF, and TGF-β. Thus, we conclude that the use of AD-MSCs may be a promising cell-based therapy for increasing immunity by accelerating neutrophil function. © 2012 Elsevier Inc. | * |
dc.language | English | * |
dc.title | Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 423 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 19 | * |
dc.relation.lastpage | 25 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2012.05.049 | * |
dc.identifier.wosid | WOS:000307087700004 | * |
dc.identifier.scopusid | 2-s2.0-84862655166 | * |
dc.author.google | Park Y.S. | * |
dc.author.google | Lim G.-W. | * |
dc.author.google | Cho K.-A. | * |
dc.author.google | Woo S.-Y. | * |
dc.author.google | Shin M. | * |
dc.author.google | Yoo E.-S. | * |
dc.author.google | Chan Ra J. | * |
dc.author.google | Ryu K.-H. | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 유은선(20936704200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 박윤신(35975370400) | * |
dc.date.modifydate | 20240118130224 | * |