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dc.contributor.author고수영-
dc.date.accessioned2016-08-28T10:08:28Z-
dc.date.available2016-08-28T10:08:28Z-
dc.date.issued2012-
dc.identifier.issn0957-4166-
dc.identifier.otherOAK-8994-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222826-
dc.description.abstract(R,S)-Reboxetine was synthesized in nine steps and with 43% overall yield starting from trans-cinnamyl alcohol. Following silylation and AD steps, the two hydroxyl groups at C-1 and C-2 were simultaneously activated to the cyclic sulfate. A series of tandem reactions initiated by desilylation transposed the activation to C-3, then to C-1, where nucleophilic displacements took place in succession. During this process, the configuration at C-2 was inverted while that at C-1 was retained through a double inversion. © 2012 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleThe synthesis of (R,S)-reboxetine employing a tandem cyclic sulfate rearrangement - Opening process-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume23-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage650-
dc.relation.lastpage654-
dc.relation.journaltitleTetrahedron Asymmetry-
dc.identifier.doi10.1016/j.tetasy.2012.04.018-
dc.identifier.wosidWOS:000306252900004-
dc.identifier.scopusid2-s2.0-84862691331-
dc.author.googleYu J.-
dc.author.googleKo S.Y.-
dc.contributor.scopusid고수영(7403325351)-
dc.date.modifydate20170508103435-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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