Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고수영 | - |
dc.date.accessioned | 2016-08-28T10:08:28Z | - |
dc.date.available | 2016-08-28T10:08:28Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0957-4166 | - |
dc.identifier.other | OAK-8994 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222826 | - |
dc.description.abstract | (R,S)-Reboxetine was synthesized in nine steps and with 43% overall yield starting from trans-cinnamyl alcohol. Following silylation and AD steps, the two hydroxyl groups at C-1 and C-2 were simultaneously activated to the cyclic sulfate. A series of tandem reactions initiated by desilylation transposed the activation to C-3, then to C-1, where nucleophilic displacements took place in succession. During this process, the configuration at C-2 was inverted while that at C-1 was retained through a double inversion. © 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | The synthesis of (R,S)-reboxetine employing a tandem cyclic sulfate rearrangement - Opening process | - |
dc.type | Article | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 650 | - |
dc.relation.lastpage | 654 | - |
dc.relation.journaltitle | Tetrahedron Asymmetry | - |
dc.identifier.doi | 10.1016/j.tetasy.2012.04.018 | - |
dc.identifier.wosid | WOS:000306252900004 | - |
dc.identifier.scopusid | 2-s2.0-84862691331 | - |
dc.author.google | Yu J. | - |
dc.author.google | Ko S.Y. | - |
dc.contributor.scopusid | 고수영(7403325351) | - |
dc.date.modifydate | 20230208103927 | - |