Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2016-08-28T10:08:27Z | - |
dc.date.available | 2016-08-28T10:08:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.other | OAK-8987 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222819 | - |
dc.description.abstract | Glycosyltransferase (GT) catalyzes the transfer of a sugar moiety to acceptor substrates such as secondary metabolites. The majority of GTs has two structural folds, GT-A and GT-B based on 3-D structural analysis. The limited structural fold diversity is compensated by a highly divergent acceptor binding domain for conferring sufficient substrate promiscuity. Various GTs have been engineered to further enhance the glucose transfer activity and expand substrate promiscuity by error-prone PCR and site-directed mutagenesis. Engineered GT-catalyzed glycosylation will certainly play a key role in the generation of scaffold for new drug discovery and control of drug pharmacokinetics. © 2012 The Korean Society of Industrial and Engineering Chemistry. | - |
dc.language | English | - |
dc.title | Glycosyltransferase and its application to glycodiversification of natural products | - |
dc.type | Review | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 18 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1208 | - |
dc.relation.lastpage | 1212 | - |
dc.relation.journaltitle | Journal of Industrial and Engineering Chemistry | - |
dc.identifier.doi | 10.1016/j.jiec.2012.01.048 | - |
dc.identifier.wosid | WOS:000306164400003 | - |
dc.identifier.scopusid | 2-s2.0-84862794688 | - |
dc.author.google | Choi S.H. | - |
dc.author.google | Kim H.S. | - |
dc.author.google | Yoon Y.J. | - |
dc.author.google | Kim D.-M. | - |
dc.author.google | Lee E.Y. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |