Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2016-08-28T10:08:27Z | - |
dc.date.available | 2016-08-28T10:08:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0887-3585 | - |
dc.identifier.other | OAK-8985 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222817 | - |
dc.description.abstract | Post-translational modification by small ubiquitin-like modifier (SUMO) can be reversed by sentrin/SUMO-specific proteases (SENPs), the first known class of deSUMOylase. Recently, we identified a new deSUMOylating enzyme DeSI-1, which is distinct from SENPs and belongs to the putative deubiquitinating isopeptidase PPPDE superfamily. Herein, we report the crystal structure of DeSI-1, revealing that this enzyme forms a homodimer and that the groove between the two subunits is the active site harboring two absolutely conserved cysteine and histidine residues that form a catalytic dyad. We also show that DeSI-1 exhibits an extremely low endopeptidase activity toward precursor forms of SUMO-1 and SUMO-2, unlike SENPs. © 2012 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.title | Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 80 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2099 | - |
dc.relation.lastpage | 2104 | - |
dc.relation.journaltitle | Proteins: Structure, Function and Bioinformatics | - |
dc.identifier.doi | 10.1002/prot.24093 | - |
dc.identifier.wosid | WOS:000306132400017 | - |
dc.identifier.scopusid | 2-s2.0-84863775612 | - |
dc.author.google | Suh H.-Y. | - |
dc.author.google | Kim J.-H. | - |
dc.author.google | Woo J.-S. | - |
dc.author.google | Ku B. | - |
dc.author.google | Shin E.J. | - |
dc.author.google | Yun Y. | - |
dc.author.google | Oh B.-H. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20200901081003 | - |