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dc.contributor.authorJunji Yodoi-
dc.date.accessioned2016-08-28T10:08:25Z-
dc.date.available2016-08-28T10:08:25Z-
dc.date.issued2012-
dc.identifier.issn1932-6203-
dc.identifier.otherOAK-8964-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222801-
dc.description.abstractBackground: Transforming growth factor beta (TGF-β) has critical roles in regulating cell growth, differentiation, apoptosis, invasion and epithelial-mesenchymal transition (EMT) of various cancer cells. TGF-β-induced EMT is an important step during carcinoma progression to invasion state. Thioredoxin binding protein-2 (TBP-2, also called Txnip or VDUP1) is downregulated in various types of human cancer, and its deficiency results in the earlier onset of cancer. However, it remains unclear how TBP-2 suppresses the invasion and metastasis of cancer. Principal Findings: In this study, we demonstrated that TBP-2 deficiency increases the transcriptional activity in response to TGF-β and also enhances TGF-β-induced Smad2 phosphorylation levels. Knockdown of TBP-2 augmented the TGF-β-responsive expression of Snail and Slug, transcriptional factors related to TGF-β-mediated induction of EMT, and promoted TGF-β-induced spindle-like morphology consistent with the depletion of E-Cadherin in A549 cells. Conclusions/Significance: Our results indicate that TBP-2 deficiency enhances TGF-β signaling and promotes TGF-β-induced EMT. The control of TGF-β-induced EMT is critical for the inhibition of the invasion and metastasis. Thus TBP-2, as a novel regulatory molecule of TGF-β signaling, is likely to be a prognostic indicator or a potential therapeutic target for preventing tumor progression. © 2012 Masaki et al.-
dc.languageEnglish-
dc.titleDeficiency of Thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume7-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitlePLoS ONE-
dc.identifier.doi10.1371/journal.pone.0039900-
dc.identifier.wosidWOS:000305892100129-
dc.identifier.scopusid2-s2.0-84863108603-
dc.author.googleMasaki S.-
dc.author.googleMasutani H.-
dc.author.googleYoshihara E.-
dc.author.googleYodoi J.-
dc.contributor.scopusidJunji Yodoi(35994345400)-
dc.date.modifydate20220112143825-


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