Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Junji Yodoi | - |
dc.date.accessioned | 2016-08-28T10:08:25Z | - |
dc.date.available | 2016-08-28T10:08:25Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | OAK-8964 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222801 | - |
dc.description.abstract | Background: Transforming growth factor beta (TGF-β) has critical roles in regulating cell growth, differentiation, apoptosis, invasion and epithelial-mesenchymal transition (EMT) of various cancer cells. TGF-β-induced EMT is an important step during carcinoma progression to invasion state. Thioredoxin binding protein-2 (TBP-2, also called Txnip or VDUP1) is downregulated in various types of human cancer, and its deficiency results in the earlier onset of cancer. However, it remains unclear how TBP-2 suppresses the invasion and metastasis of cancer. Principal Findings: In this study, we demonstrated that TBP-2 deficiency increases the transcriptional activity in response to TGF-β and also enhances TGF-β-induced Smad2 phosphorylation levels. Knockdown of TBP-2 augmented the TGF-β-responsive expression of Snail and Slug, transcriptional factors related to TGF-β-mediated induction of EMT, and promoted TGF-β-induced spindle-like morphology consistent with the depletion of E-Cadherin in A549 cells. Conclusions/Significance: Our results indicate that TBP-2 deficiency enhances TGF-β signaling and promotes TGF-β-induced EMT. The control of TGF-β-induced EMT is critical for the inhibition of the invasion and metastasis. Thus TBP-2, as a novel regulatory molecule of TGF-β signaling, is likely to be a prognostic indicator or a potential therapeutic target for preventing tumor progression. © 2012 Masaki et al. | - |
dc.language | English | - |
dc.title | Deficiency of Thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 7 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | PLoS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0039900 | - |
dc.identifier.wosid | WOS:000305892100129 | - |
dc.identifier.scopusid | 2-s2.0-84863108603 | - |
dc.author.google | Masaki S. | - |
dc.author.google | Masutani H. | - |
dc.author.google | Yoshihara E. | - |
dc.author.google | Yodoi J. | - |
dc.contributor.scopusid | Junji Yodoi(35994345400) | - |
dc.date.modifydate | 20220112143825 | - |