Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-28T10:08:23Z | - |
dc.date.available | 2016-08-28T10:08:23Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.other | OAK-8944 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222784 | - |
dc.description.abstract | Hyaluronic acid (HA) has been shown to promote angio-genesis. However, the mechanism behind this effect remains largely unknown. Therefore, in this study, the mechanism of HA-induced angiogenesis was examined. CD44 and PKCδ were shown to be necessary for induction of the receptor for HA-mediated cell motility (RHAMM), a HA-binding protein. RHAMM was necessary for HA-pro-moted cellular invasion and endothelial cell tube formation. Cytokine arrays showed that HA induced the expression of plasminogen activator-inhibitor-1 (PAI), a downstream target of TGFβ receptor signaling. The induction of PAI-1 was dependent on CD44 and PKCδ. HA also induced an interaction between RHAMM and TGFβ receptor I, and induction of PAI-1 was dependent on RHAMM and TGFβ receptor I. Histone deacetylase 3 (HDAC3), which is decreased by HA via rac1, reduced induction of plasminogen activator inhibitor-1 (PAI-1) by HA. ERK, which interacts with RHAMM, was necessary for induction of PAI-1 by HA. Snail, a downstream target of TGFβ signaling, was also necessary for induction of PAI-1. The down regulation of PAI-1 prevented HA from enhancing endothelial cell tube formation and from inducing expression of angiogenic factors, such as ICAM-1, VCAM-1 and MMP-2. HDAC3 also exerted reduced expression of MMP-2. In this study, we provide a novel mechanism of HA-promoted angiogenesis, which involved RHAMM-TGFβRI signaling necessary for induction of PAI-1. © 2012 KSMCB. | * |
dc.language | English | * |
dc.title | Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 563 | * |
dc.relation.lastpage | 574 | * |
dc.relation.journaltitle | Molecules and Cells | * |
dc.identifier.doi | 10.1007/s10059-012-2294-1 | * |
dc.identifier.wosid | WOS:000305691100005 | * |
dc.identifier.scopusid | 2-s2.0-84863466133 | * |
dc.author.google | Park D. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Kim H. | * |
dc.author.google | Kim K. | * |
dc.author.google | Lee Y.-S. | * |
dc.author.google | Choe J. | * |
dc.author.google | Hahn J.-H. | * |
dc.author.google | Lee H. | * |
dc.author.google | Jeon J. | * |
dc.author.google | Choi C. | * |
dc.author.google | Kim Y.-M. | * |
dc.author.google | Jeoung D. | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |