Beta-carboline alkaloids derived from the ascidian Synoicum sp.

Abstract

Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y 1 (7) and six new derivatives, designated eudistomins Y 8-Y 13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na +/K +-ATPase. Structure-activity relationships were also deduced. © 2012 Elsevier Ltd. All rights reserved.